ArticleJournal of biomedical optics2017
Evaluation of a pointwise microcirculation assessment method using liquid and multilayered tissue simulating phantoms.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Enhancing skin tone representation in optical vascular phantoms.Journal of biomedical optics · 2026Article
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- A Cost-Effective Method for the Spectral Calibration of Photoplethysmography Pulses: The Optimal Wavelengths for Heart Rate Monitoring.Sensors (Basel, Switzerland) · 2025Article
- Absorption and reduced scattering coefficients in epidermis and dermis from a Swedish cohort study.Journal of biomedical optics · 2023Article
- Laser Doppler Flowmetry Combined with Spectroscopy to Determine Peripheral Tissue Perfusion and Oxygen Saturation: A Pilot Study in Healthy Volunteers and Patients with Peripheral Arterial Disease.Journal of personalized medicine · 2022Article
- Multispectral snapshot imaging of skin microcirculatory hemoglobin oxygen saturation using artificial neural networks trained on in vivo data.Journal of biomedical optics · 2022Article
- Vasomotion analysis of speed resolved perfusion, oxygen saturation, red blood cell tissue fraction, and vessel diameter: Novel microvascular perspectives.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Spectral characterization of liquid hemoglobin phantoms with varying oxygenation states.Journal of biomedical optics · 2021Article
- Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties.Journal of biomedical optics · 2021Article
- Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient.Journal of biophotonics · 2021Article
- Estimation of skin microcirculatory hemoglobin oxygen saturation and red blood cell tissue fraction using a multispectral snapshot imaging system: a validation study.Journal of biomedical optics · 2021Article
- Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy.Journal of biomedical optics · 2020Article
- Validation of speed-resolved laser Doppler perfusion in a multimodal optical system using a blood-flow phantom.Journal of biomedical optics · 2019Article
- Impact of hemoglobin breakdown products in the spectral analysis of burn wounds using spatial frequency domain spectroscopy.Journal of biomedical optics · 2019Article
- Recovery of layered tissue optical properties from spatial frequency-domain spectroscopy and a deterministic radiative transport solver.Journal of biomedical optics · 2018Article
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Authors and funding
4 authors.
Funding
Abstract
A fiber-optic probe-based instrument, designed for assessment of parameters related to microcirculation, red blood cell tissue fraction (fRBC), oxygen saturation (SO2), and speed resolved perfusion, has been evaluated using state-of-the-art tissue phantoms. The probe integrates diffuse reflectance spectroscopy (DRS) at two source-detector separations and laser Doppler flowmetry, using an inverse Monte Carlo method for identifying the parameters of a multilayered tissue model. Here, we characterize the accuracy of the DRS aspect of the instrument using (1) liquid blood phantoms containing yeast and (2) epidermis-dermis mimicking solid-layered phantoms fabricated from polydimethylsiloxane, titanium oxide, hemoglobin, and coffee. The root-mean-square (RMS) deviations for fRBC for the two liquid phantoms were 11% and 5.3%, respectively, and 11% for the solid phantoms with highest hemoglobin signatures. The RMS deviation for SO2 was 5.2% and 2.9%, respectively, for the liquid phantoms, and 2.9% for the solid phantoms. RMS deviation for the reduced scattering coefficient (μs'), for the solid phantoms was 15% (475 to 850 nm). For the liquid phantoms, the RMS deviation in average vessel diameter (D) was 1 μm. In conclusion, the skin microcirculation parameters fRBC and SO2, as well as, μs' and D are estimated with reasonable accuracy.
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