ReviewNeurocritical care2018
The Ictal-Interictal Continuum: To Treat or Not to Treat (and How)?
Review in Neurocritical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06017973 (The Role of Cerebral Functional, Structural and Spectral Imaging in the Diagnosis, Management and Prognosis of Status Epilepticus), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cerebral Functional, Structural and Spectral Imaging in the Diagnosis, Management and Prognosis of Status Epilepticus: a Prospective Study in Patients with the Ictal-interictal Continuum
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Intracranial EEG for Detecting Epileptic Activity in Acute Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Review
- Electroencephalography Monitoring for Seizure Risk Stratification in the Critically III.Current neurology and neuroscience reports · 2026Review
- Intracranial electroencephalographic approaches in the intensive care unit: Safety, feasibility, and coverage.Epilepsia · 2026Article
- Defining the end point of status epilepticus: A scoping review and framework for standardization.Epilepsia · 2026Article
- Ictal-interictal continuum and status epilepticus: Two sides of the same coin? A prospective magnetic resonance imaging study.Epilepsia · 2026Article
- Pitfalls in ICU EEG Interpretation: A Retrospective Case Series.The Neurohospitalist · 2026Article
- Identification of nonconvulsive status epilepticus in the ictal-interictal continuum using artificial intelligence: a prospective observational cohort study.Encephalitis (Seoul, Korea) · 2026Article
- Automating Critical Care EEG: Enhancing Accuracy, Efficiency, and Patient Outcomes in Critical Care.Epilepsy currents · 2026Article
- Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy.Clinical neurophysiology practice · 2026Review
- Using artificial intelligence to optimize anti-seizure treatment and EEG-guided decisions in severe brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Ictal-Interictal Continuum in the Pediatric Intensive Care Unit.Neurocritical care · 2024Article
- Article
- Effects of epileptiform activity on discharge outcome in critically ill patients in the USA: a retrospective cross-sectional study.The Lancet. Digital health · 2023Article
- Prognosis of consciousness disorders in the intensive care unit.Presse medicale (Paris, France : 1983) · 2023Review
- Periodic discharges in veterinary electroencephalography-A visual review.Frontiers in veterinary science · 2023Review
- Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring.Neurocritical care · 2022Observational
- Factors associated with the use of anesthetic drug infusion in patients with status epilepticus and their relation to outcome: a prospective study.Acta neurologica Belgica · 2022Article
- Monitoring the Burden of Seizures and Highly Epileptiform Patterns in Critical Care with a Novel Machine Learning Method.Neurocritical care · 2021Article
- Deep active learning for Interictal Ictal Injury Continuum EEG patterns.Journal of neuroscience methods · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous electroencephalography (cEEG) monitoring is becoming increasingly used in neurologic and non-neurologic intensive care units (ICUs). Non-convulsive seizures (NCSz) and periodic discharges (PDs) are commonly seen in critically ill patients. Some of these PD patterns, also known as the ictal-interictal continuum (IIC), are associated with an increased risk of seizures and poor outcome. However, we do not fully understand the significance of these periodic patterns and the decision of how aggressively to treat remains controversial. IIC patterns are associated with pathophysiologic changes that closely resemble those of seizures. Here we make the argument that, rather than feature description on EEG, associated changes in brain physiology should dictate management choices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.