Evidence map›Paper›PMID 29139007›Full record

Trial reportBreast cancer research and treatment2018

Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial.

Sara Mijwel, Malin Backman, Kate A Bolam, Anna Jervaeus, Carl Johan Sundberg, Sara Margolin, Maria Browall, Helene Rundqvist, Yvonne Wengström

Registry-linked trialOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02522260 (OptiTrain - Optimal Training for Women With Breast Cancer During Chemotherapy Treatment), which is not on this map. Cited by 99 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 30 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02522260 nacompletednot on this map

OptiTrain - Optimal Training for Women With Breast Cancer During Chemotherapy Treatment

TypeinterventionalSponsorKarolinska InstitutetRan2013 to 2021Enrolled240ConditionsWell BeingArmsResistance and aerobic training, Aerobic training, Standard supportive care
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 30 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Efficacy of different non-pharmacological therapies on cancer-related fatigue in breast cancer patients: a network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
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  4. The effects of aerobic and resistance training across eight cancer types: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  5. Pooled it
  6. The effect of exercise on cognitive function in breast cancer survivors: systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  7. Pooled it
  8. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  9. Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024
    Pooled it
  10. Impact of resistance training on fatigue among breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  11. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  12. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  13. Pooled it
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  15. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
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  18. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  19. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  20. Pooled it

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sara MijwelDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Sara.Mijwel@ki.se.ORCID http://orcid.org/0000-0002-6718-5797
Malin BackmanDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Kate A BolamDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Anna JervaeusDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Carl Johan SundbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Sara MargolinDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Maria BrowallDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Helene RundqvistDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Yvonne WengströmDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEThe University of Queensland · AUUniversity of Skövde · SE

Funding

Cancerfonden 130452Cancerföreningen i Stockholm 131242Svenska Läkaresällskapet SLS50514The Swedish Cancer and Traffic Accident Foundation F-C-001225
6 · The paper itself

Abstract

purposeExercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.

methodsTwo hundred and forty women planned to undergo chemotherapy were randomized to supervised RT-HIIT, AT-HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.

resultsThe RT-HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT-HIIT compared to declines shown in the UC group (p = 0.04). AT-HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT-HIIT reported a reduced symptom burden, while AT-HIIT remained stable compared to deteriorations shown by UC (p < 0.01). Only RT-HIIT was superior to UC for total symptoms (p < 0.01).

conclusions16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.

trial registrationClinicaltrials.gov Registration Number: NCT02522260.

Indexed as

High-Intensity Interval TrainingAdultAntineoplastic AgentsBreast NeoplasmsExercise TherapyFatigueFemaleHumansMiddle AgedPhysical FitnessQuality of LifeTreatment OutcomeAntineoplastic AgentsBreast cancerChemotherapyConcurrent trainingHealth-related quality of lifeHigh-intensity interval trainingSymptom burden

Identifiers

PMID29139007
PMCPMC5847033
OpenAlexW2769880098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.