ArticleParasitology research2018
Blastocystis subtypes isolated from irritable bowel syndrome patients and co-infection with Helicobacter pylori.
Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Is there an association betweenWorld journal of gastroenterology · 2019Pooled it
- Blastocystis, an Enigmatic Parasite.Acta parasitologica · 2026Review
- Association of Blastocystis species subtypes 3 and 4 with intestinal inflammation and response to metronidazole in symptomatic patients.BMC infectious diseases · 2026Article
- Frequency and predictive role of intestinal parasitic infections with irritable bowel syndrome in Egyptian patients: a case-control study.Infection · 2026Article
- Genotyping of Blastocystis species in hemodialysis patients from Makkah, Saudi Arabia.Parasites, hosts and diseases · 2026Article
- Assessment of the Therapeutic Role of Allium tuncelianum Extract in Rats Infected with Blastocystis Subtype 3.Acta parasitologica · 2025Article
- The Role ofPathogens (Basel, Switzerland) · 2025Review
- Investigation ofAfrican health sciences · 2025Article
- Blastocystis hominis; Friend or Foe.Integrative medicine (Encinitas, Calif.) · 2024Review
- Effect ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Unveiling Blastocystis epidemiology in Morocco: subtype diversity among clinical patients with and without gastrointestinal manifestations in the Meknes region.Parasitology research · 2024Article
- The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.Gut pathogens · 2024Article
- Molecular Epidemiology and Genetic Diversity of the Enteric Protozoan ParasitePathogens (Basel, Switzerland) · 2023Article
- Genetic characteristics of Blastocystis sp. ST3 at the genome level in the Chinese population.Parasitology research · 2023Article
- Subtypes and phylogenetic analysis of Blastocystis sp. isolates from West Ismailia, Egypt.Scientific reports · 2022Article
- An Association Between Blastocystis Subtypes and Colorectal Cancer Patients: A Significant Different Profile from Non-cancer Individuals.Acta parasitologica · 2022Article
- Anti-blastocystosis activity of antioxidant coated ZIF-8 combined with mesoporous silicas MCM-41 and KIT-6.Scientific reports · 2022Article
- Article
- Detection, Molecular Identification and Transmission of the Intestinal ProtozoaMicroorganisms · 2022Article
- Intestinal parasitic infections and associated risk factors in diabetic patients: a case-control study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease presenting clinically by abdominal pain with alteration of bowel habits. Although IBS has uncertain etiology, chronic gut inflammation due to persistent exposure to an infectious agent including Blastocystis sp. was proposed. The aim of this study was to detect the prevalence of Blastocystis sp. subtype (ST) isolated from stool of IBS patients and to assess Blastocystis sp. and H. pylori co-infection in IBS patients from Beni-Suef Governorate, Egypt. Stool samples were collected from 115 IBS patients, following Rome III criteria. All stool samples were microscopically examined by wet mount and permanent trichrome stain, cultured on Jones' medium with further sequencing of positive Blastocystis isolates and screened for detection of H. pylori coproantigen. Blastocystis sp. was the predominant parasite in IBS patients; it had statistical significant association with both rural residence (OR = 10) and flatulence (OR = 8.2). There was a predominance of Blastocystis sp. ST3 (81%) followed by ST1 (19%). Blastocystis culture results (19.1%) were superior than microscopy (16.5%). The majority of Blastocystis-positive IBS patients (72.7%) were co-infected with H. pylori with statistical significance; however, H. pylori was higher in Blastocystis-negative IBS patients (47/64) than in Blastocystis-positive IBS patients (17/64). Interestingly, IBS is usually associated with gut dysbiosis, while the most prevalent parasite in our IBS patients was Blastocystis sp., which is frequently found in asymptomatic individuals. Whether Blastocystis sp. is a cause or a consequence of IBS still needs further investigation, with a particular focus on correlation of IBS with different Blastocystis sp. subtypes and gut microbiomes.
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