Evidence map›Paper›PMID 29138913›Full record

ArticleWorld journal of surgery2018

Postoperative Albumin-Bilirubin Grade Change Predicts the Prognosis of Patients with Hepatitis B-Related Hepatocellular Carcinoma Within the Milan Criteria.

Chuan Li, Xiao-Yun Zhang, Wei Peng, Tian-Fu Wen, Lu-Nan Yan, Bo Li, Jia-Yin Yang, Wen-Tao Wang, Ming-Qing Xu

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Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuan LiDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Xiao-Yun ZhangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Wei PengDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tian-Fu WenDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China. aderwe@163.com.
Lu-Nan YanDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Bo LiDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Jia-Yin YangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Wen-Tao WangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ming-Qing XuDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.

Funding

Health and Family Planning Commission of Sichuan Province 17PJ393Science and Technological Supports Project of Sichuan Province 2015SZ0049Science and Technological Supports Project of Sichuan Province 2016SZ0025
6 · The paper itself

Abstract

objectiveAlbumin-bilirubin (ALBI) grade has been validated as a simple, evidence-based, and objective prognostic tool for patients with hepatocellular carcinoma (HCC). However, minimal information is available concerning postoperative ALBI grade changes in HCC. This study aimed to investigate the prognostic value of postoperative ALBI grade changes in patients with hepatitis B virus (HBV)-related HCC within the Milan criteria after liver resection.

methodsPatients with HBV-related HCC within the Milan criteria who underwent liver resection between 2010 and 2016 at West China Hospital were reviewed (N = 258). A change in ALBI grade was defined as first postoperative month ALBI grade-preoperative ALBI grade. If the value was >0, postoperative worsening of ALBI grade was considered; otherwise, stable ALBI grade was considered. Cox proportional hazard regression analyses were used to determine the factors that influence recurrence and survival.

resultsDuring the follow-up, 130 patients experienced recurrence and 47 patients died. Multivariate analyses revealed that postoperative worsening of ALBI grade (HR 1.541, 95% CI 1.025-2.318, P = 0.038), microvascular invasion (MVI, HR 1.802, 95% CI 1.205-2.695, P = 0.004), and multiple tumors (HR 1.676, 95% CI 1.075-2.615, P = 0.023) were associated with postoperative recurrence, whereas MVI (HR 2.737, 95% CI 1.475-5.080, P = 0.001), postoperative worsening of ALBI grade (HR 2.268, 95% CI 1.227-4.189, P = 0.009), high alpha-fetoprotein level (HR 2.055, 95% CI 1.136-3.716, P = 0.017), and transfusion (HR 2.597, 95% CI 1.395-4.834, P = 0.003) negatively influenced long-term survival. Patients with postoperative worsening of ALBI grade exhibited increased incidence of recurrence and worse long-term survival.

conclusionPostoperative worsening of ALBI grade was associated with increased recurrence and poorer overall survival for patients with HBV-related HCC within the Milan criteria. We should pay attention to liver function changes in HCC patients after liver resection.

Indexed as

AdultAgedBilirubinCarcinoma, HepatocellularFemaleHepatitis BHumansLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisProportional Hazards ModelsRetrospective StudiesSerum AlbuminBilirubinSerum Albumin

Identifiers

PMID29138913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.