Evidence map›Paper›PMID 29138605›Full record

ReviewOpen access journal of sports medicine2017

Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.

Philip D Chilibeck, Mojtaba Kaviani, Darren G Candow, Gordon A Zello

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Open access journal of sports medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 110 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04058002 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Project Arthritis Recovering Quality of Life Through Education 70+

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2019 to 2020Enrolled34ConditionsKnee OsteoarthritisArmsMultiprofessional treatment and Educational Program Associated (EPA+C+BCAA) with supplementation of creatine and BCAA., Multiprofessional treatment and Educational Program Associated (EPA+C) with supplementation of creatine only.
NCT04290819 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Creatine and Caffeine Co-Supplementation on Muscle Mass and Muscle Performance in Trained Young Adults

TypeinterventionalSponsorUniversity of ReginaRan2019 to 2020Enrolled36ConditionsPerformance Enhancing Product UseArmsCreatine Monohydrate, Creatine Monohydrate and Caffeine, Caffeine, Placebo
NCT07580846 recruitingnot on this mapstarted 2026, after this paper: background citation

AssessmenT of thE Adherence of Nutritional Supplementation With Creatine Formula in Estrogen-Depleted Adult Women: Prospective Clinical Investigation

TypeobservationalSponsorMargan BiotechRan2026 to 2026Enrolled100ConditionsMenopause, Estrogen Deficiency
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 22 syntheses or guidelines pooled it.

  1. Creatine supplementation in soccer players: a systematic review.Journal of the International Society of Sports Nutrition · 2026
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Philip D ChilibeckCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK.
Mojtaba KavianiSchool of Nutrition and Dietetics, Acadia University, Wolfville, NS.
Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina.
Gordon A ZelloCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The loss of muscle mass and strength with aging results in significant functional impairment. Creatine supplementation has been used in combination with resistance training as a strategy for increasing lean tissue mass and muscle strength in older adults, but results across studies are equivocal. We conducted a systematic review and meta-analysis of randomized controlled trials of creatine supplementation during resistance training in older adults with lean tissue mass, chest press strength, and leg press strength as outcomes by searching PubMed and SPORTDiscus databases. Twenty-two studies were included in our meta-analysis with 721 participants (both men and women; with a mean age of 57-70 years across studies) randomized to creatine supplementation or placebo during resistance training 2-3 days/week for 7-52 weeks. Creatine supplementation resulted in greater increases in lean tissue mass (mean difference =1.37 kg [95% CI =0.97-1.76];

Indexed as

agebench pressexerciseleg pressmusclenutritionsarcopenia

Identifiers

PMID29138605
PMCPMC5679696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.