Evidence map›Paper›PMID 29138529›Full record

ArticleDisease markers2017

Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma.

Danijela Štrbac, Katja Goričar, Vita Dolžan, Viljem Kovač

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463290 (Association of Single Nucleotide Polymorphisms), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04463290 unknown statusnot on this mapstarted 2020, after this paper: background citation

Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.

TypeobservationalSponsorAristotle University Of ThessalonikiRan2020 to 2022Enrolled200ConditionsMetalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek PopulationArmsNo intervention, Patients selection based on clinical symptoms and radiological imaging
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Danijela ŠtrbacInstitute of Oncology Ljubljana, Ljubljana, Slovenia.
Katja GoričarPharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-5673-4458
Vita DolžanPharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-6707-6649
Viljem KovačInstitute of Oncology Ljubljana, Ljubljana, Slovenia.ORCID 0000-0003-0379-9041
Institute of Oncology Ljubljana · SIUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalignant pleural mesothelioma (MPM) is a rare disease with a relatively short overall survival (OS). Metalloproteinases (MMPs) have a vast biological effect on tumor progression, invasion, metastasis formation, and apoptosis. MMP expression was previously associated with survival in MPM. Our aim was to evaluate if genetic variability of

methodsWe genotyped 199 MPM patients for ten polymorphisms: rs243865, rs243849 and rs7201, in

resultsCarriers of polymorphic

conclusionsSelected

Indexed as

Polymorphism, Single NucleotideAgedBiomarkers, TumorFemaleHeterozygoteHumansLung NeoplasmsMaleMatrix MetalloproteinasesMesotheliomaMesothelioma, MalignantMiddle AgedBiomarkers, TumorMatrix Metalloproteinases

Identifiers

PMID29138529
PMCPMC5613362
OpenAlexW2754835439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.