ArticleScientific reports2017
Bone regeneration is associated with the concentration of tumour necrosis factor-α induced by sericin released from a silk mat.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- The Application of L-Serine-Incorporated Gelatin Sponge into the Calvarial Defect of the Ovariectomized Rats.Tissue engineering and regenerative medicine · 2025Article
- Relevant Properties and Potential Applications of Sericin in Bone Regeneration.Current issues in molecular biology · 2023Review
- Effect of degumming degree on the structure and tensile properties of RSF/RSS composite films prepared by one-step extraction.Scientific reports · 2023Article
- The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin.Maxillofacial plastic and reconstructive surgery · 2023Article
- 4-Hexylresorcinol Treatment before Degumming Increases the β-Sheet Structure of Silk Sericin and BMP-2 Expression in RAW264.7 Cells.International journal of molecular sciences · 2022Article
- Administration of 4‑hexylresorcinol increases p53‑mediated transcriptional activity in oral cancer cells with the p53 mutation.Oncology reports · 2022Article
- Retrospective comparative clinical study for silk mat application into extraction socket.Maxillofacial plastic and reconstructive surgery · 2019Article
- 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways.Scientific reports · 2019Article
- The effects of proteins released from silk mat layers on macrophages.Maxillofacial plastic and reconstructive surgery · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the osteogenic effect of the middle layer of the silk cocoon, sericin was examined for its cellular effects associated with tumor necrosis factor-α (TNF-α) signaling in this study. The fragmented sericin proteins in the silk mat were evaluated for the TNF-α expression level in murine macrophages. The concentration of protein released from silk mats was higher in the outermost and the innermost layers than in the middle layers, and the protein released from the silk mat was identified as sericin. The level of TNF-α in murine macrophages was dependent on the applied concentration of sericin, and the expression of genes associated with osteogenesis in osteoblast-like cells was dependent on the applied concentration of TNF-α. In animal experiments, silk mats from the middle layers led to a higher regenerated bone volume than silk mats from the innermost layer or the outermost layer. If TNF-α protein was incorporated into the silk mats from the middle layers, bone regeneration was suppressed compared with unloaded silk mats from the middle layers. Accordingly, silk mats from the silk cocoon can be considered to be a fragmented sericin-secreting carrier, and the level of sericin secretion is associated with TNF-α induction and bone regeneration.
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