ArticleScientific reports2017
Functional annotation of structural ncRNAs within enhancer RNAs in the human genome: implications for human disease.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Role of eRNAs in Cardiovascular Diseases.Current cardiology reviews · 2026Review
- Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci.Nature communications · 2025Article
- eRNA-IDO: A One-stop Platform for Identification, Interactome Discovery, and Functional Annotation of Enhancer RNAs.Genomics, proteomics & bioinformatics · 2024Article
- Enhancer RNAs step forward: new insights into enhancer function.Development (Cambridge, England) · 2022Article
- Review
- Enhancer RNA: What we know and what we can achieve.Cell proliferation · 2022Review
- The Biological Roles of lncRNAs and Future Prospects in Clinical Application.Diseases (Basel, Switzerland) · 2021Review
- Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses.Frontiers in immunology · 2021Review
- Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells.Nucleic acids research · 2020Article
- Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective.Nucleic acids research · 2020Article
- Critical roles of super-enhancers in the pathogenesis of autoimmune diseases.Inflammation and regeneration · 2020Review
- Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci.Frontiers in genetics · 2020Review
- Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding.Nature communications · 2019Article
- Prevalence of chromosomal abnormalities identified by copy number variation sequencing in high-risk pregnancies, spontaneous abortions, and suspected genetic disorders.The Journal of international medical research · 2019Article
- Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate.Frontiers in cell and developmental biology · 2019Review
- From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions.Frontiers in oncology · 2019Review
- Review
- Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer.BioMed research international · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancer RNAs (eRNAs) are a novel class of non-coding RNA (ncRNA) molecules transcribed from the DNA sequences of enhancer regions. Despite extensive efforts devoted to revealing the potential functions and underlying mechanisms of eRNAs, it remains an open question whether eRNAs are mere transcriptional noise or relevant biologically functional species. Here, we identified a catalogue of eRNAs in a broad range of human cell/tissue types and extended our understanding of eRNAs by demonstrating their multi-omic signatures. Gene Ontology (GO) analysis revealed that eRNAs play key roles in human cell identity. Furthermore, we detected numerous known and novel functional RNA structures within eRNA regions. To better characterize the cis-regulatory effects of non-coding variation in these structural ncRNAs, we performed a comprehensive analysis of the genetic variants of structural ncRNAs in eRNA regions that are associated with inflammatory autoimmune diseases. Disease-associated variants of the structural ncRNAs were disproportionately enriched in immune-specific cell types. We also identified riboSNitches in lymphoid eRNAs and investigated the potential pathogenic mechanisms by which eRNAs might function in autoimmune diseases. Collectively, our findings offer valuable insights into the function of eRNAs and suggest that eRNAs might be effective diagnostic and therapeutic targets for human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.