ArticleNature communications2017
The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Comparative Metabolomics ofJournal of microbiology and biotechnology · 2025Article
- Phylogenomics and genetic analysis of solvent-producing Clostridium species.Scientific data · 2024Article
- Total Synthesis of Clostrienose.ACS omega · 2023Article
- The Lanthipeptide Synthetase-like Protein CA_C0082 Is an Effector of Agr Quorum Sensing inMicroorganisms · 2023Article
- Chromosomal engineering of inducible isopropanol- butanol-ethanol production inFrontiers in bioengineering and biotechnology · 2023Article
- Identification of serine/threonine kinases that regulate metabolism and sporulation in Clostridium beijerinckii.Applied microbiology and biotechnology · 2022Article
- Enzymology of standalone elongating ketosynthases.Chemical science · 2022Review
- Decoding the roles of extremophilic microbes in the anaerobic environments: Past, Present, and Future.Current research in microbial sciences · 2022Review
- Production of Hexanol as the Main Product Through Syngas Fermentation byFrontiers in bioengineering and biotechnology · 2022Article
- Mining and unearthing hidden biosynthetic potential.Nature communications · 2021Review
- Sporulation in solventogenic and acetogenic clostridia.Applied microbiology and biotechnology · 2021Review
- Deeper below the surface-transcriptional changes in selected genes of Clostridium beijerinckii in response to butanol shock.MicrobiologyOpen · 2021Article
- Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Discovery and Biosynthesis of Clostyrylpyrones from the Obligate AnaerobeOrganic letters · 2020Article
- Metabolic characterisation ofRSC advances · 2020Article
- RRNPP-type quorum sensing affects solvent formation and sporulation inMicrobiology (Reading, England) · 2020Article
- Microbial Musings - June 2020.Microbiology (Reading, England) · 2020Article
- Investigation of secondary metabolism in the industrial butanol hyper-producer Clostridium saccharoperbutylacetonicum N1-4.Journal of industrial microbiology & biotechnology · 2020Article
- Transcriptomic and Phenotypic Analysis of aFrontiers in microbiology · 2020Article
- Metabolic Engineering of Histidine Kinases inFrontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Polyketides are an important class of bioactive small molecules valued not only for their diverse therapeutic applications, but also for their role in controlling interesting biological phenotypes in their producing organisms. While numerous polyketides are known to be derived from aerobic organisms, only a single family of polyketides has been identified from anaerobic organisms. Here we uncover a family of polyketides native to the anaerobic bacterium Clostridium acetobutylicum, an organism well-known for its historical use as an industrial producer of the organic solvents acetone, butanol, and ethanol. Through mutational analysis and chemical complementation assays, we demonstrate that these polyketides act as chemical triggers of sporulation and granulose accumulation in this strain. This study represents a significant addition to the body of work demonstrating the existence and importance of polyketides in anaerobes, and showcases a strategy of manipulating the secondary metabolism of an organism to improve traits relevant for industrial applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.