Evidence map›Paper›PMID 29138320›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Structural basis for antibody recognition of the NANP repeats in

David Oyen, Jonathan L Torres, Ulrike Wille-Reece, Christian F Ockenhouse, Daniel Emerling, Jacob Glanville, Wayne Volkmuth, Yevel Flores-Garcia, Fidel Zavala, Andrew B Ward and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 160 citations in OpenAlex.

  1. Trial
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  5. Protective near-germline antibodies to malaria elicited by RTS,S/AS01bioRxiv : the preprint server for biology · 2026
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  11. Review
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  17. Machine learning enables de novo multiepitope design ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

David OyenDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Jonathan L TorresDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Ulrike Wille-ReecePATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, DC 20001.
Christian F OckenhousePATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, DC 20001.
Daniel EmerlingAtreca Inc., Redwood City, CA 94063.
Jacob GlanvilleDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305.
Wayne VolkmuthAtreca Inc., Redwood City, CA 94063.
Yevel Flores-GarciaMalaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Fidel ZavalaMalaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
C Richter KingPATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, DC 20001.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; wilson@scripps.edu.
Scripps Research Institute · USItasca Consultants (United States) · USJohns Hopkins University · USStanford University · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NIGMS NIH HHS P41 GM103393NIH HHS S10 OD012289
6 · The paper itself

Abstract

Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against

Indexed as

AnimalsAntibodies, ProtozoanAntigens, ProtozoanClinical Trials, Phase II as TopicCrystallography, X-RayEpitope MappingEpitopesHumansMalaria, FalciparumMalaria VaccinesMiceMice, Inbred C57BLPlasmodium falciparumProtozoan ProteinsRecombinant ProteinsRepetitive Sequences, Amino AcidAntibodies, ProtozoanAntigens, Protozoancircumsporozoite protein, ProtozoanEpitopesMalaria VaccinesProtozoan ProteinsRecombinant Proteinsantibodiescircumsporozoite proteinEMmalariaX-ray crystallography

Identifiers

PMID29138320
PMCPMC5715787
OpenAlexW2769957615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.