ArticleProceedings of the National Academy of Sciences of the United States of America2017
Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA.Nature communications · 2026Article
- Ectopic Gene Conversion Causing Quantitative Trait Variation.Molecular biology and evolution · 2025Article
- Reconstruction of Segmental Duplication Rates and Associated Genomic Features by Network Analysis.Genome biology and evolution · 2025Article
- Estimating Gene Conversion Tract Length and Rate From PacBio HiFi Data.Molecular biology and evolution · 2025Article
- Coordinated evolution of the SNORD115 and SNORD116 tandem repeats at the imprinted Prader-Willi/Angelman locus.NAR molecular medicine · 2024Article
- Interlocus Gene Conversion, Natural Selection, and Paralog Homogenization.Molecular biology and evolution · 2023Article
- Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays.BMC biology · 2023Article
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- Silencing RNAs expressed from W-linkedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Variant calling: Considerations, practices, and developments.Human mutation · 2022Review
- Phylogenetic and Molecular Analyses Identify SNORD116 Targets Involved in the Prader-Willi Syndrome.Molecular biology and evolution · 2022Article
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- The vitellogenin genes in Cynops orientalis: New insights on the evolution of the vtg gene family in amphibians.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Article
- Concerted evolution reveals co-adapted amino acid substitutions in NaCurrent biology : CB · 2021Article
- Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence.BMC genomics · 2021Article
- Article
- Organelle Phylogenomics and Extensive Conflicting Phylogenetic Signals in the Monocot Order Poales.Frontiers in plant science · 2021Article
- Demographic inference from multiple whole genomes using a particle filter for continuous Markov jump processes.PloS one · 2021Article
- Quantifying Influences on Intragenomic Mutation Rate.G3 (Bethesda, Md.) · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gene conversion is the copying of a genetic sequence from a "donor" region to an "acceptor." In nonallelic gene conversion (NAGC), the donor and the acceptor are at distinct genetic loci. Despite the role NAGC plays in various genetic diseases and the concerted evolution of gene families, the parameters that govern NAGC are not well characterized. Here, we survey duplicate gene families and identify converted tracts in 46% of them. These conversions reflect a large GC bias of NAGC. We develop a sequence evolution model that leverages substantially more information in duplicate sequences than used by previous methods and use it to estimate the parameters that govern NAGC in humans: a mean converted tract length of 250 bp and a probability of [Formula: see text] per generation for a nucleotide to be converted (an order of magnitude higher than the point mutation rate). Despite this high baseline rate, we show that NAGC slows down as duplicate sequences diverge-until an eventual "escape" of the sequences from its influence. As a result, NAGC has a small average effect on the sequence divergence of duplicates. This work improves our understanding of the NAGC mechanism and the role that it plays in the evolution of gene duplicates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.