Evidence map›Paper›PMID 29138303›Full record

ArticlemBio2017

CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens.

Matthew A Crawford, Debra J Fisher, Lisa M Leung, Sara Lomonaco, Christine Lascols, Antonio Cannatelli, Tommaso Giani, Gian Maria Rossolini, Yohei Doi, David R Goodlett and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Matthew A CrawfordDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Debra J FisherDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Lisa M LeungDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Sara LomonacoCenter for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA.
Christine LascolsNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Antonio CannatelliDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Tommaso GianiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
David R GoodlettDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Marc W AllardCenter for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA.
Shashi K SharmaCenter for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA.
Erum KhanDepartment of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan.
Robert K ErnstDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Molly A HughesDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA mah3x@virginia.edu.
Center for Food Safety and Applied Nutrition · USUniversity of Maryland, Baltimore · USUniversity of Virginia · USUniversity of Siena · ITAga Khan University · PKNational Center for Emerging and Zoonotic Infectious Diseases · USUniversity of Florence · ITUniversity of Pittsburgh · US

Funding

Bacillus anthracis Targets Involved in Chemokine-Mediated Antimicrobial ActivityR01AI099097 · NIAID · UNIVERSITY OF VIRGINIA · PI HUGHES, MOLLY A · 2013 to 2016
$1.6M
Molecular study of DksA as a smart switch central to Salmonella pathogenesisF32AI108249 · NIAID · UNIVERSITY OF VIRGINIA · PI CRAWFORD, MATTHEW ANTHONY · 2014 to 2016
$155k
NIAID NIH HHS F32 AI108249NIAID NIH HHS R01 AI099097
6 · The paper itself

Abstract

The continued rise and spread of antimicrobial resistance among bacterial pathogens pose a serious challenge to global health. Countering antimicrobial-resistant pathogens requires a multifaceted effort that includes the discovery of novel therapeutic approaches. Here, we establish the capacity of the human CXC chemokines CXCL9 and CXCL10 to kill multidrug-resistant Gram-negative bacteria, including New Delhi metallo-beta-lactamase-1-producing

Indexed as

Anti-Bacterial AgentsBacterial ProteinsChemokine CXCL10Chemokine CXCL9EnterobacteriaceaeHumansMicrobial ViabilityAnti-Bacterial AgentsBacterial ProteinsChemokine CXCL10Chemokine CXCL9CXCL10 protein, humanCXCL9 protein, humanPhoP protein, BacteriaPhoQ protein, Bacteriaantimicrobial resistancecarbapenemchemokinecolistinGram negative

Identifiers

PMID29138303
PMCPMC5686536
OpenAlexW2768660021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.