Evidence map›Paper›PMID 29138290›Full record

ReviewDevelopment (Cambridge, England)2017

Developing a sense of touch.

Blair A Jenkins, Ellen A Lumpkin

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Blair A JenkinsDepartment of Physiology & Cellular Biophysics and Department of Dermatology, Columbia University in the City of New York, New York, NY 10032, USA.
Ellen A LumpkinDepartment of Physiology & Cellular Biophysics and Department of Dermatology, Columbia University in the City of New York, New York, NY 10032, USA eal2166@columbia.edu.ORCID 0000-0002-1166-3374

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Mechanisms of mechanosensory transduction in Merkel cellsR01AR051219 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUMPKIN, ELLEN A · 2004 to 2020
$6.0M
Peripheral Mechanisms Governing Tactile Encoding During Normal Target RemodelingR01NS073119 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GERLING, GREGORY JOHN, LUMPKIN, ELLEN A · 2010 to 2016
$2.5M
How do discriminative touch receptors selectively innervate peripheral targets?F31NS094023 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JENKINS, BLAIR ADDISON · 2015 to 2018
$188k
NIAMS NIH HHS R01 AR051219NIGMS NIH HHS T32 GM007367NINDS NIH HHS F31 NS094023NINDS NIH HHS R01 NS073119
6 · The paper itself

Abstract

The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and relay signals from the periphery to the central nervous system. During embryogenesis, axons elongate from these neurons to make contact with the developing skin. Concurrently, the epithelium of skin transforms from a homogeneous tissue into a heterogeneous organ that is made up of distinct layers and microdomains. Throughout this process, each neuronal terminal must form connections with an appropriate skin region to serve its function. This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them.

Indexed as

AnimalsBody PatterningHumansMechanoreceptorsNeuronsSensationSkinTouchAxon guidanceHair follicleMerkel cellPlacodeSkinTouch

Identifiers

PMID29138290
PMCPMC5719243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.