Evidence map›Paper›PMID 29138281›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations

Farah H Bardai, Liqun Wang, Yamini Mutreja, Mythili Yenjerla, T Chris Gamblin, Mel B Feany

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. ThebioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
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  5. m6A-dependent circular RNA formation mediates tau-induced neurotoxicity.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. TauCell reports methods · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its PathogenicityThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  14. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. MAPT mutations, tauopathy, and mechanisms of neurodegeneration.Laboratory investigation; a journal of technical methods and pathology · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Farah H BardaiDepartment of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, and.ORCID 0000-0002-1998-2572
Liqun WangDepartment of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, and.
Yamini MutrejaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045.
Mythili YenjerlaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045.
T Chris GamblinDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045 gamblin@ku.edu mel_feany@hms.harvard.edu.
Mel B FeanyDepartment of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, and gamblin@ku.edu mel_feany@hms.harvard.edu.
Brigham and Women's Hospital · USUniversity of Kansas · US

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI STEVENS, BETH ANN · 2016 to 2020
$5.2M
Biochemical and in vivo determinants of tau neurotoxicityR01NS083391 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI FEANY, MEL B, GAMBLIN, TRUMAN C · 2012 to 2015
$1.9M
NICHD NIH HHS U54 HD090255NINDS NIH HHS R01 NS083391
6 · The paper itself

Abstract

The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.

Indexed as

CytoskeletonActinsAnimalsAnimals, Genetically ModifiedAutophagyConserved SequenceDrosophilaHumansMutagenesis, InsertionalMutationPhosphorylationSignal TransductionTauopathiestau ProteinsUnfolded Protein ResponseActinsMAPT protein, humantau ProteinsAlzheimer'sDrosophilatau

Identifiers

PMID29138281
PMCPMC5761430
OpenAlexW2768415339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.