Evidence map›Paper›PMID 29138280›Full record

ArticleGenes & development2017

Foxp1 regulation of neonatal vocalizations via cortical development.

Noriyoshi Usui, Daniel J Araujo, Ashwinikumar Kulkarni, Marissa Co, Jacob Ellegood, Matthew Harper, Kazuya Toriumi, Jason P Lerch, Genevieve Konopka

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

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  19. Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Noriyoshi UsuiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Daniel J AraujoDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Ashwinikumar KulkarniDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Marissa CoDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Jacob EllegoodMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Ontario M5S 1A1, Canada.
Matthew HarperDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Kazuya ToriumiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Jason P LerchMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Ontario M5S 1A1, Canada.
Genevieve KonopkaDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
The University of Texas Southwestern Medical Center · USHospital for Sick Children · CAKanazawa University · JPUniversity of Toronto · CA

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
The role of Foxp1-regulated signaling pathways in brain development and behaviorR01MH102603 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2015 to 2019
$2.2M
Functional dissection of mammalian vocal communicationR01DC014702 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2016 to 2020
$1.7M
Mechanisms of Disease & Translational ScienceT32GM109776 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI YIN, HELEN L · 2014 to 2018
$573k
UT Southwestern Center for Translational Medicine (UL18Kl2/TL1)TL1TR001104 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$418k
CIHRHoward Hughes Medical InstituteNCATS NIH HHS TL1 TR001104NCATS NIH HHS UL1 TR001105NIDCD NIH HHS R01 DC014702NIGMS NIH HHS T32 GM109776NIMH NIH HHS R01 MH102603
6 · The paper itself

Abstract

The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 in both brain development and ASD pathophysiology. However, the specific molecular pathways both upstream of and downstream from FOXP1 are not fully understood. To elucidate the contribution of FOXP1-mediated signaling to brain development and, in particular, neocortical development, we generated forebrain-specific

Indexed as

Vocalization, AnimalAnimalsCell MovementForkhead Transcription FactorsGene DeletionGene ExpressionMi-2 Nucleosome Remodeling and Deacetylase ComplexMice, KnockoutNeocortexNeuritesNeuronsProsencephalonProtein Inhibitors of Activated STATRepressor ProteinsSignal TransductionSmall Ubiquitin-Related Modifier ProteinsForkhead Transcription FactorsFoxp1 protein, mouseMi-2 Nucleosome Remodeling and Deacetylase ComplexProtein Inhibitors of Activated STATRepressor ProteinsSmall Ubiquitin-Related Modifier Proteinsautismbehaviorneocortexneurogenomicsneuronal migrationsumoylation

Identifiers

PMID29138280
PMCPMC5733496
OpenAlexW2769636270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.