Evidence map›Paper›PMID 29138279›Full record

ArticleGenes & development2017

The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function.

Jaeda C Coutinho-Budd, Amy E Sheehan, Marc R Freeman

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Article
  3. Single-cell sequencing reveals potential novel insights into appendage-patterning and joint-development in a spider.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Regulating glial morphogenesis: insights fromFrontiers in cell and developmental biology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Reduced expression ofJournal of Parkinson's disease · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jaeda C Coutinho-BuddDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Amy E SheehanVollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA.
Marc R FreemanVollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA.
Vollum Institute · USUniversity of Massachusetts Chan Medical School · US

Funding

The Draper signaling pathway in Drosophila glial immune functionsR01NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Marc R Freeman · 2006 to 2026
$5.3M
Astrocyte control of neural circuits and behaviorR37NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEMAN, MARC R · 2016 to 2022
$2.9M
Transmission Electron Microscope for Core EM FacilityS10RR027897 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2009 to 2009
$500k
Cellular and molecular mechanisms regulating glial growth control and survivalF32NS089203 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI COUTINHO-BUDD, JAEDA · 2014 to 2014
$5k
NCRR NIH HHS S10 RR027897NINDS NIH HHS F32 NS089203NINDS NIH HHS R01 NS053538NINDS NIH HHS R37 NS053538
6 · The paper itself

Abstract

Most glial functions depend on establishing intimate morphological relationships with neurons. Significant progress has been made in understanding neuron-glia signaling at synaptic and axonal contacts, but how glia support neuronal cell bodies is unclear. Here we explored the growth and functions of

Indexed as

AnimalsAstrocytesBehavior, AnimalBrainCell SurvivalDrosophila melanogasterDrosophila ProteinsMembrane FusionMorphogenesisNeurogliaNeuronsRNA InterferenceDrosophila ProteinsSpz3 protein, Drosophilacortex gliaDrosophilaglianeurotrophinspz3αSNAP

Identifiers

PMID29138279
PMCPMC5733495
OpenAlexW2770012336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.