Evidence map›Paper›PMID 29138264›Full record

ArticleBioscience reports2017

Comprehensive investigation of cytokine- and immune-related gene variants in HBV-associated hepatocellular carcinoma patients.

Fengxue Yu, Xiaolin Zhang, Suzhai Tian, Lianxia Geng, Weili Xu, Ning Ma, Mingbang Wang, Yuan Jia, Xuechen Liu, Junji Ma and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Histology and histopathology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Role ofBioscience reports · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Fengxue YuDepartment of Science and Technology, The Hebei Key Laboratory of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China fengxue2002yu202356@hotmail.com.
Xiaolin ZhangDivision of Epidemiology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Suzhai TianDepartment of Science and Technology, The Hebei Key Laboratory of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lianxia GengDepartment of Science and Technology, The Hebei Key Laboratory of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Weili XuDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Ning MaDivision of Epidemiology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Mingbang WangDepartment of Central Laboratory, Shenzhen Following Precision Medical Research Institute, Shenzhen, Guangdong, China.
Yuan JiaDepartment of Infectious Disease Control, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Xuechen LiuDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Junji MaDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yuan QuanDepartment of Infectious Disease, Hebei Chest Hospital, Shijiazhuang, China.
Chaojun ZhangDepartment of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lina GuoDepartment of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Wenting AnDepartment of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Dianwu LiuDivision of Epidemiology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Hebei Medical University · CNSecond Hospital of Hebei Medical University · CNHospital of Hebei Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host genotype may be closely related to the different outcomes of Hepatitis B virus (HBV) infection. To identify the association of variants and HBV infection, we comprehensively investigated the cytokine- and immune-related gene mutations in patients with HBV associated hepatocellular carcinoma (HBV-HCC). Fifty-three HBV-HCC patients, 53 self-healing cases (SH) with HBV infection history and 53 healthy controls (HCs) were recruited, the whole exon region of 404 genes were sequenced at >900× depth. Comprehensive variants and gene levels were compared between HCC and HC, and HCC and SH. Thirty-nine variants (adjusted

Indexed as

AdultCarcinoma, HepatocellularCase-Control StudiesCytokinesExonsFemaleGenotypeHepatitis B, ChronicHepatitis B virusHumansLiver NeoplasmsMaleMiddle AgedMutationCytokinescytokinegene level associationHBV-HCCimmune genesTarget Region Sequencing (TRS)

Identifiers

PMID29138264
PMCPMC5725607
OpenAlexW2769186372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.