ArticleThe American journal of pathology1989
Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages.
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- CaThe Journal of biological chemistry · 2017Article
- Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis.The Journal of biological chemistry · 2017Article
- Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.mBio · 2015Article
- Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages.Journal of virology · 2011Article
- Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Frustrated phagocytosis on micro-patterned immune complexes to characterize lysosome movements in live macrophages.Frontiers in immunology · 2011Article
- A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Endocytosis of activated receptors and clathrin-coated pit formation: deciphering the chicken or egg relationship.The Journal of cell biology · 1996Article
- Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages.The Journal of cell biology · 1993Article
- Granulomatous reaction and tissue remodelling in the cutaneous lesion of chromomycosis.Virchows Archiv. A, Pathological anatomy and histopathology · 1993Article
- Role of the Golgi apparatus in cellular pathology.Journal of electron microscopy technique · 1991Review
- Directed exocytosis of secretory granules containing apolipoprotein E to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes.The American journal of pathology · 1989Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The authors have observed the rapid reorganization of the cellular membranes of macrophages during Fc receptor-mediated frustrated phagocytosis of immune complex-coated surfaces. As the macrophages spread, large, clear basal vacuoles and anastamosing tubules were formed, occasionally contiguous with the adherent surface. Coated vesicles also were observed. This process was accompanied by a rapid reorganization of the Golgi complex region of the macrophages, which was observed using trimetaphosphatase histochemistry and an antibody to a Golgi membrane antigen as markers. On contact of the macrophages with the immune complexes, the Golgi complexes, which were tightly clustered around the centrioles, dispersed into vesicles and reorganized near the basal surface. The Golgi cisternae swelled, fragmented, and decreased in number. Golgi membrane antigen was found in the large basal vacuoles and also associated with the adherent basal surface of the macrophages. This indicates that the Golgi complexes were reorganized, in part, by a direct recruitment of their membranes to the increasing basal surface area of the spreading macrophages. The changes in the structure of the Golgi complexes were reversible; by 2 hours, the complexes had recovered their normal organization, with an accompanying decrease in the number of large basal vacuoles. These data suggest that the dynamic interrelationship among the Golgi membranes, intracellular vacuoles, and the plasma membrane can be perturbed by membrane spreading on a nonphagocytosable surface.
Indexed as
Identifiers
2913823PMC1879551W338907495What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.