Evidence map›Paper›PMID 29138181›Full record

Trial reportJournal of the American Heart Association2017

One-Year Outcome of Intensive Insulin Therapy Combined to Glucose-Insulin-Potassium in Acute Coronary Syndrome: A Randomized Controlled Study.

Wahid Bouida, Kaouthar Beltaief, Mohamed Amine Msolli, Nasri Bzeouich, Adel Sekma, Malek Echeikh, Malek Mzali, Hamdi Boubaker, Mohamed Habib Grissa, Riadh Boukef and 7 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00965406 (Glucose Insulin Potassium With Intensive Insulin Therapy and), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00965406 phase3completednot on this map

Glucose Insulin Potassium With Intensive Insulin Therapy and (GIK2) Versus GIK Alone in the Early Management of Acute Coronary Syndrome: Randomised Controlled Study

TypeinterventionalSponsorUniversity of MonastirRan2010 to 2014Enrolled772ConditionsAcute Coronary SyndromeArmsGIK and intensive insulin therapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Wahid BouidaEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Kaouthar BeltaiefEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Mohamed Amine MsolliEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Nasri BzeouichEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Adel SekmaEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Malek EcheikhEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Malek MzaliEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Hamdi BoubakerEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Mohamed Habib GrissaEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Riadh BoukefEmergency Department, Sahloul University Hospital, Sousse, Tunisia.
Mohsen HassineHematology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Zohra DridiCardiology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Asma BelguithDepartment of Preventive Medicine, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Fadhel NajjarBiochemistry Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Ines KhochtaliDepartment of Internal Medicine and Endocrinology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Semir NouiraEmergency Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia semir.nouira@rns.tn.
GREAT Network
Hospital Fatuma Bourguiba Monastir · TNUniversity of Monastir · TNHôpital Sahloul · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA number of factors may offset the cardioprotective effects of glucose-insulin-potassium (GIK) on outcome of patients with acute coronary syndrome, such as hyperglycemia induced by this cocktail infusion. We performed a study to evaluate the effect of intensive insulin therapy in association with GIK on 1-year outcome in patients hospitalized for acute coronary syndrome. METHODS AND

resultsIn a randomized prospective controlled trial we included 772 patients with non-ST-segment elevation acute coronary syndrome. Patients were randomized into 3 groups: GIKI

conclusionsGIKI CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00965406.

Indexed as

ElectrocardiographyAcute Coronary SyndromeCardioplegic SolutionsDose-Response Relationship, DrugDrug Therapy, CombinationFemaleFollow-Up StudiesGlucoseHumansHypoglycemic AgentsInsulinMaleMiddle AgedPotassiumProspective StudiesTime FactorsCardioplegic SolutionsGlucoseglucose-insulin-potassium cardioplegic solutionHypoglycemic AgentsInsulinPotassiumacute coronary syndromeglucose‐insulin‐potassiumintensive insulin therapypharmacologyprognosis

Identifiers

PMID29138181
PMCPMC5721763
OpenAlexW2770003565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.