ArticleInternational journal for parasitology2018
Clearance of schistosome parasites by resistant genotypes at a single genomic region in Biomphalaria glabrata snails involves cellular components of the hemolymph.
Article in International journal for parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins.PLoS neglected tropical diseases · 2024Article
- Heat shock increases hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata.Fish & shellfish immunology · 2020Article
- Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors.eLife · 2020Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
- Article
- Gene drives for schistosomiasis transmission control.PLoS neglected tropical diseases · 2019Review
- Allelic variation in a single genomic region alters the hemolymph proteome in the snail Biomphalaria glabrata.Fish & shellfish immunology · 2019Article
- Allelic Variation in a Single Genomic Region Alters the Microbiome of the Snail Biomphalaria glabrata.The Journal of heredity · 2018Article
- Gene buddies: linked balanced polymorphisms reinforce each other even in the absence of epistasis.PeerJ · 2018Article
- Proteomic Analysis ofFrontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Schistosomiasis is one of the most detrimental neglected tropical diseases. Controlling the spread of this parasitic illness requires effective sanitation, access to chemotherapeutic drugs, and control over populations of the freshwater snails, such as Biomphalaria glabrata, that are essential intermediate hosts for schistosomes. Effectively controlling this disease, while minimising ecological implications of such control, will require an extensive understanding of the immunological interactions between schistosomes and their molluscan intermediate hosts. Here we histologically characterise the clearance of schistosome larvae by snails that exhibit allelic variation at a single genomic region, the Guadeloupe resistance complex. We show that snails with a resistant Guadeloupe resistance complex genotype clear schistosomes within the first 24-48 h, and that this resistance can be transferred to susceptible snails via whole hemolymph but not cell-free plasma. These findings imply that Guadeloupe resistance complex-coded proteins help to coordinate hemocyte-mediated immune responses to schistosome infections in Guadeloupean snails.
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Registered trials
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