Evidence map›Paper›PMID 29137952›Full record

ArticleThe American journal of pathology2018

Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3-Mediated Indian Hedgehog Signaling.

Chenshuang Li, Zhong Zheng, Jie Jiang, Wenlu Jiang, Kevin Lee, Emily A Berthiaume, Eric C Chen, Cymbeline T Culiat, Yan-Heng Zhou, Xinli Zhang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Chenshuang LiSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California; Department of Orthodontics, Peking University, School and Hospital of Stomatology, Beijing, People's Republic of China.
Zhong ZhengSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California.
Jie JiangUCLA Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, California.
Wenlu JiangSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California; State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Kevin LeeSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California.
Emily A BerthiaumeDavid Geffen School of Medicine at UCLA, University of California, Los Angeles, California.
Eric C ChenSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California.
Cymbeline T CuliatOak Ridge National Laboratory, Oak Ridge, Tennessee.
Yan-Heng ZhouDepartment of Orthodontics, Peking University, School and Hospital of Stomatology, Beijing, People's Republic of China.
Xinli ZhangSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California.
Kang TingSection of Orthodontics, Division of Growth and Development, School of Dentistry, University of California, Los Angeles, California; UCLA Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, California. Electronic address: kting@dentistry.ucla.edu.
Chia SooUCLA Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, California. Electronic address: bsoo@ucla.edu.
University of California, Los Angeles · USOak Ridge National Laboratory · USPeking University · CNState Key Laboratory of Oral Diseases

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
Wnt and PPARy Signaling in Nell-1 and BMP2 Mediated Bone RegenerationR01AR061399 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA · 2012 to 2016
$1.7M
NCATS NIH HHS UL1 TR000124NIAMS NIH HHS R01 AR061399NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01 AR068835
6 · The paper itself

Abstract

The pro-chondrogenic function of runt-related transcription factor 2 (Runx2) was previously considered to be dependent on direct binding with the promoter of Indian hedgehog (Ihh)-the major regulator of chondrocyte differentiation, proliferation, and maturation. The authors' previous studies identified neural EGFL like 1 (Nell-1) as a Runx2-responsive growth factor for chondrogenic differentiation and maturation. In this study, it was further revealed that the pro-chondrogenic activities of Nell-1 also rely on Ihh signaling, by showing: i) Nell-1 significantly elevated Ihh signal transduction; ii) Nell-1 deficiency markedly reduced Ihh activation in chondrocytes; and iii) Nell-1-stimulated chondrogenesis was significantly reduced by the specific hedgehog inhibitor cyclopamine. Importantly, the authors demonstrated that Nell-1-responsive Ihh signaling and chondrogenic differentiation extended to Runx2

Indexed as

AnimalsCalcium-Binding ProteinsCartilageCell DifferentiationCells, CulturedChondrocytesChondrogenesisCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 3 SubunitGlycoproteinsHedgehog ProteinsMice, KnockoutSignal TransductionCalcium-Binding ProteinsCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 3 SubunitGlycoproteinsHedgehog Proteinsihh protein, mouseNell1 protein, mouseRunx2 protein, mouseRunx3 protein, mouse

Identifiers

PMID29137952
PMCPMC5785559
OpenAlexW2767206797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.