ArticleSchizophrenia research2018
Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder.Human brain mapping · 2021Pooled it
- Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.The European journal of neuroscience · 2022Article
- Context-specific abnormalities of the central executive network in first-episode psychosis: relationship with cognition.Psychological medicine · 2022Article
- Anger Experience and Anger Expression Through Drawing in Schizophrenia: An fNIRS Study.Frontiers in psychology · 2021Article
- Functional Connectivity During Visuospatial Processing in Schizophrenia: A Classification Study Using Lasso Regression.Neuropsychiatric disease and treatment · 2021Article
- Lateralized evoked responses in parietal cortex demonstrate visual short-term memory deficits in first-episode schizophrenia.Journal of psychiatric research · 2020Article
- Are working memory and glutamate concentrations involved in early-life stress and severity of psychosis?Brain and behavior · 2020Article
- Intrinsic Connectivity of the Globus Pallidus: An Uncharted Marker of Functional Prognosis in People With First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- Association Between Duration of Untreated Psychosis and Frontostriatal Connectivity During Maintenance of Visuospatial Working Memory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Increased Functional Coupling between VTA and Hippocampus during Rest in First-Episode Psychosis.eNeuroArticle
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Authors and funding
7 authors.
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Abstract
introductionWe probed the neural basis of working memory in individuals with first episode of psychosis (FEP) and assessed how these neural abnormalities are associated with behavioral performance and/or core to psychosis pathophysiology.
methodsFEP (N=35) and matched controls (N=25) performed a visuospatial working memory task during fMRI acquisition. We isolated neural activity during the maintenance period and examined neural activity within regions typically engaged during a working memory task. Functional connectivity estimates were derived using psychophysiological interaction analysis. We examined correlations between brain function and behavioral performance and clinical symptomatology.
resultsFEP had reduced accuracy and slower reaction times compared to controls (p<0.05, q<0.05). During the maintenance period, FEP exhibited reduced right dorsolateral prefrontal cortex (DLPFC) activation compared to controls (p=0.007, q=0.01), even when behavioral performance was matched between groups (p=0.01, q=0.03). Unlike controls, FEP failed to show increased dorsal anterior cingulate (dACC) activity with increased load level (p=0.02, q=0.06). Compared to controls, FEP showed increased negative DLPFC-dACC coupling during the maintenance period (p=0.05). Increased DLPFC activation was significantly associated with greater negative symptoms (p<0.005, q=0.02), while greater dACC activation was significantly associated with better performance in FEP (p<0.05, q<0.17).
conclusionWM impairment in psychosis may be specific to abnormalities in the ability of frontal systems processing executive commands (DLPFC) and monitoring performance (dACC) during the maintenance of information. Our results add to accumulating evidence indicating that DLPFC abnormalities may be core to psychosis psychopathology. We also provide new insights regarding how DLPFC abnormalities may undermine dACC processing during the maintenance of information.
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