Evidence map›Paper›PMID 29137655›Full record

Trial reportTrials2017

Can integrating the Memory Support Intervention into cognitive therapy improve depression outcome? Study protocol for a randomized controlled trial.

Allison G Harvey, Lu Dong, Jason Y Lee, Nicole B Gumport, Steven D Hollon, Sophia Rabe-Hesketh, Kerrie Hein, Kirsten Haman, Mary E McNamara, Claire Weaver and 4 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01790919 phase2completednot on this map

Improving Depression Outcome by Enhancing Memory for Cognitive Therapy

TypeinterventionalSponsorUniversity of California, BerkeleyRan2013 to 2015Enrolled48ConditionsMajor Depressive Disorder (MDD)ArmsCognitive therapy for depression
NCT07666672 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Randomized Controlled Trial of the BraveBot Intervention as an Adjunctive Treatment for Young People With Anxiety and Related Disorders Receiving Outpatient, Exposure-Based Cognitive Behavioral Therapy

TypeinterventionalSponsorMassachusetts General HospitalRan2026 to 2027Enrolled50ConditionsAnxiety Disorders, OCDArmsBraveBot, Self-Guided Exposure Therapy Homework
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Allison G HarveyDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA. aharvey@berkeley.edu.
Lu DongDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Jason Y LeeDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Nicole B GumportDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Steven D HollonVanderbilt University, Nashville, TN, USA.
Sophia Rabe-HeskethDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Kerrie HeinDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Kirsten HamanVanderbilt University, Nashville, TN, USA.
Mary E McNamaraDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Claire WeaverDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Armando MartinezDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Haruka NotsuDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Garret ZieveDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.
Courtney C ArmstrongDepartment of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA.

Funding

Improving Depression Outcome by Enhancing Memory for Cognitive TherapyR01MH108657 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARVEY, ALLISON G · 2016 to 2019
$3.0M
National Institute of Mental Health R01MH108657NIMH NIH HHS R01 MH108657
6 · The paper itself

Abstract

backgroundThe Memory Support Intervention was developed in response to evidence showing that: (1) patient memory for treatment is poor, (2) poor memory for treatment is associated with poorer adherence and poorer outcome, (3) the impact of memory impairment can be minimized by the use of memory support strategies and (4) improved memory for treatment improves outcome. The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether the Memory Support Intervention improves illness course and functional outcomes. As a "platform" for the next step in investigating this approach, we focus on major depressive disorder (MDD) and cognitive therapy (CT). METHOD/

designAdults with MDD (n = 178, including 20% for potential attrition) will be randomly allocated to CT + Memory Support or CT-as-usual and will be assessed at baseline, post treatment and at 6 and 12 months' follow-up (6FU and 12FU). We will compare the effects of CT + Memory Support vs. CT-as-usual to determine if the new intervention improves the course of illness and reduces functional impairment (aim 1). We will determine if patient memory for treatment mediates the relationship between treatment condition and outcome (aim 2). We will evaluate if previously reported poor treatment response subgroups moderate target engagement (aim 3). DISCUSSION: The Memory Support Intervention has been developed to be "transdiagnostic" (relevant to a broad range of mental disorders) and "pantreatment" (relevant to a broad range of types of treatment). This study protocol describes a "next step" in the treatment development process by testing the Memory Support Intervention for major depressive disorder (MDD) and cognitive therapy (CT). If the results are promising, future directions will test the applicability to other kinds of interventions and disorders and in other settings.

trial registrationClinicalTrials.gov, ID: NCT01790919 . Registered on 6 October 2016.

Indexed as

AffectCognitionCognitive Behavioral TherapyMemoryCaliforniaClinical ProtocolsFemaleHumansMajor Depressive DisorderMaleMiddle AgedProspective StudiesResearch DesignTime FactorsTreatment OutcomeCognitive therapyDepressionExperimental therapeuticsMemory supportTransdiagnostic

Identifiers

PMID29137655
PMCPMC5686897

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.