ArticleSensors (Basel, Switzerland)2017
A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva.
Article in Sensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Beyond Sensitivity: A Perspective on Transitioning Photonic Sensors into Real-Life Applications.Sensors (Basel, Switzerland) · 2026Review
- Article
- AuNP/Magnetic Bead-Enhanced Electrochemical Sensor Toward Dual Saliva Alzheimer's Biomarkers Detection.Sensors (Basel, Switzerland) · 2025Article
- Nanosensors and Microsensors for Body Fluid Monitoring: Various Analyte Detection and Construction Solutions.International journal of molecular sciences · 2025Review
- Optical Detection Techniques for Biomedical Sensing: A Review of Printed Circuit Board (PCB)-Based Lab-on-Chip Systems.Micromachines · 2025Review
- High-sensitivity flip chip blue Mini-LEDs miniaturized optical instrument for non-invasive glucose detection.Discover nano · 2024Article
- Monitoring saliva compositions for non-invasive detection of diabetes using a colorimetric-based multiple sensor.Scientific reports · 2023Article
- A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes.Biosensors · 2023Article
- Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation.International journal of oral science · 2023Review
- Reshaping healthcare with wearable biosensors.Scientific reports · 2023Article
- Saliva-based microfluidic point-of-care diagnostic.Theranostics · 2023Review
- Optical Measurement of Molar Absorption Coefficient of HbA1c: Comparison of Theoretical and Experimental Results.Sensors (Basel, Switzerland) · 2022Article
- Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review.Sensors (Basel, Switzerland) · 2022Review
- Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Application of a Novel Biosensor for Salivary Conductivity in Detecting Chronic Kidney Disease.Biosensors · 2022Article
- Recent Advances in Wearable Optical Sensor Automation Powered by Battery versus Skin-like Battery-Free Devices for Personal Healthcare-A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Comprehensive Review on Wearable Sweat-Glucose Sensors for Continuous Glucose Monitoring.Sensors (Basel, Switzerland) · 2022Review
- Sense and Learn: Recent Advances in Wearable Sensing and Machine Learning for Blood Glucose Monitoring and Trend-Detection.Frontiers in bioengineering and biotechnology · 2022Review
- Nanoplasmonic Strip Test for Salivary Glucose Monitoring.Nanomaterials (Basel, Switzerland) · 2021Article
- Derivation and validation of gray-box models to estimate noninvasive in-vivo percentage glycated hemoglobin using digital volume pulse waveform.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A lab-on-a-chip (LOC)-based non-invasive optical sensor for measuring glucose in saliva was fabricated. Existing glucose sensors utilizing blood require acquisition of a blood sample by pricking the finger, which is painful and inconvenient. To overcome these limitations, we propose a non-invasive glucose sensor with LOC, micro-electro-mechanical system and optical measurement technology. The proposed sensor for measuring glucose in saliva involves pretreatment, mixing, and measurement on a single tiny chip. Saliva containing glucose and glucose oxidase for glucose oxidation are injected through Inlets 1 and 2, respectively. Next, H₂O₂ is produced by the reaction between glucose and glucose oxidase in the pretreatment part. The saliva and generated H₂O₂ are mixed with a colorizing agent injected through Inlet 3 during the mixing part and the absorbance of the colorized mixture is measured in the measurement part. The absorbance of light increases as a function of glucose concentration at a wavelength of 630 nm. To measure the absorbance of the colorized saliva, a light-emitting diode with a wavelength of 630 nm and a photodiode were used during the measurement part. As a result, the measured output current of the photodiode decreased as glucose concentration in the saliva increased.
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Registered trials
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