Evidence map›Paper›PMID 29137196›Full record

ArticleInternational journal of molecular sciences2017

High Expression of STAT3 in Subcutaneous Adipose Tissue Associates with Cardiovascular Risk in Women with Rheumatoid Arthritis.

Mitra Nadali, Rille Pullerits, Karin M E Andersson, Sofia Töyrä Silfverswärd, Malin C Erlandsson, Maria I Bokarewa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mitra NadaliDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. mitra.nadali@rheuma.gu.se.
Rille PulleritsDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. rille.pullerits@rheuma.gu.se.
Karin M E AnderssonDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. karin.andersson@rheuma.gu.se.
Sofia Töyrä SilfverswärdDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. sofia.silfversward@rheuma.gu.se.
Malin C ErlandssonDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. malin.erlandsson@rheuma.gu.se.
Maria I BokarewaDepartment of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 46 Gothenburg, Sweden. maria.bokarewa@rheuma.gu.se.
University of Gothenburg · SESahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the predominance of female patients and uncommon obesity, rheumatoid arthritis (RA) is tightly connected to increased cardiovascular morbidity. The aim of this study was to investigate transcriptional activity in the subcutaneous white adipose tissue (WAT) with respect to this disproportionate cardiovascular risk (CVR) in RA. CVR was estimated in 182 female patients, using the modified Systematic Coronary Risk Evaluation scale, and identified 93 patients with increased CVR. The overall transcriptional activity in WAT was significantly higher in patients with CVR and was presented by higher serum levels of WAT products leptin, resistin and IL-6 (all,

Indexed as

AdultArthritis, RheumatoidBiomarkersCardiovascular DiseasesCase-Control StudiesFemaleHumansInterleukin-6Middle AgedNF-kappa BProto-Oncogene Proteins c-aktSTAT3 Transcription FactorSubcutaneous FatAKT1 protein, humanBiomarkersInterleukin-6NF-kappa BProto-Oncogene Proteins c-aktSTAT3 protein, humanSTAT3 Transcription Factoradipose tissuecardiovascular riskIL6leptinrheumatoid arthritisSTAT3

Identifiers

PMID29137196
PMCPMC5713378
OpenAlexW2767648546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.