ArticleNucleic acids research2018
Structure and electrical properties of DNA nanotubes embedded in lipid bilayer membranes.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Targeting DNA termini with a small-molecule natural product analogue: a DNA end-binder (DEB) to augment DNA double-strand breaks.Nucleic acids research · 2025Article
- Lateral nanoarchitectonics from nano to life: ongoing challenges in interfacial chemical science.Chemical science · 2024Review
- Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.Nature communications · 2023Article
- All-Atom Molecular Dynamics Simulations of Membrane-Spanning DNA Origami Nanopores.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Triggered Assembly of a DNA-Based Membrane Channel.Journal of the American Chemical Society · 2022Article
- The Fusion of Lipid and DNA Nanotechnology.Genes · 2019Review
- Controlling aggregation of cholesterol-modified DNA nanostructures.Nucleic acids research · 2019Article
- Dynamic Interactions between Lipid-Tethered DNA and Phospholipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineering the synthetic nanopores through lipid bilayer membrane to access the interior of a cell is a long persisting challenge in biotechnology. Here, we demonstrate the stability and dynamics of a tile-based 6-helix DNA nanotube (DNT) embedded in POPC lipid bilayer using the analysis of 0.2 μs long equilibrium MD simulation trajectories. We observe that the head groups of the lipid molecules close to the lumen cooperatively tilt towards the hydrophilic sugar-phosphate backbone of DNA and form a toroidal structure around the patch of DNT protruding in the membrane. Further, we explore the effect of ionic concentrations to the in-solution structure and stability of the lipid-DNT complex. Transmembrane ionic current measurements for the constant electric field MD simulation provide the I-V characteristics of the water filled DNT lumen in lipid membrane. With increasing salt concentrations, the measured values of transmembrane ionic conductance of the porous DNT lumen vary from 4.3 to 20.6 nS. Simulations of the DNTs with ssDNA and dsDNA overhangs at the mouth of the pore show gating effect with remarkable difference in the transmembrane ionic conductivities for open and close state nanopores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.