Evidence map›Paper›PMID 29136240›Full record

ArticleNeurosurgery2018

Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy.

Bennet Omalu, Gary W Small, Julian Bailes, Linda M Ercoli, David A Merrill, Koon-Pong Wong, Sung-Cheng Huang, Nagichettiar Satyamurthy, Jennifer L Hammers, John Lee and 2 more

Registry-linked trialAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02003183 (FDDNP-PET Imaging in Persons at Risk for Chronic Traumatic Encephalopathy), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02003183 completednot on this map

FDDNP-PET Imaging in Persons at Risk for Chronic Traumatic Encephalopathy

TypeobservationalSponsorUniversity of California, Los AngelesRan2013 to 2018Enrolled24ConditionsCTE, TBI (Traumatic Brain Injury)Arms[F-18]FDDNP
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. A brief history of Aβ imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Molecular neurodegeneration · 2025
    Article
  5. Review
  6. A case of cognitive impairment in an ex-boxer.Journal of family medicine and primary care · 2024
    Article
  7. Review
  8. Recent Research onMolecules (Basel, Switzerland) · 2023
    Review
  9. Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  18. Bibliometric Analysis of Chronic Traumatic Encephalopathy Research from 1999 to 2019.International journal of environmental research and public health · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bennet OmaluDepartment of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California.
Gary W SmallDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California.
Julian BailesDepartment of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois.
Linda M ErcoliDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California.
David A MerrillDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California.
Koon-Pong WongDepartment of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California.
Sung-Cheng HuangDepartment of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California.
Nagichettiar SatyamurthyDepartment of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California.
Jennifer L HammersOffice of Chief Medical Examiner, City of New York, New York.
John LeeDepartment of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois.
Robert P FitzsimmonsFitzsimmons Law Firm PLLC, Wheeling, West Virginia.
Jorge R BarrioDepartment of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California.

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
VISUALIZING BRAIN A-BETA, TAU /SEROTONIN RECEPTOR DENSITP01AG025831 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 2005 to 2010
$7.0M
NCRR NIH HHS M01 RR000865NIA NIH HHS P01 AG025831
6 · The paper itself

Abstract

Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients.

Indexed as

AutopsyBrainBrain Injury, ChronicChronic Traumatic EncephalopathyFootballHumansMaleMiddle AgedPositron-Emission TomographyAntemortemAutopsyCTE[F-18]FDDNP-PETFootball player

Identifiers

PMID29136240
PMCPMC6685403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.