Evidence map›Paper›PMID 29136208›Full record

ArticleNucleic acids research2018

Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice.

Molly A Bogue, Stephen C Grubb, David O Walton, Vivek M Philip, Georgi Kolishovski, Tim Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe and 2 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Frontiers in immunology · 2025
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  17. System-level analyses of keystone genes required for mammalian tooth development.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Molly A BogueThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Stephen C GrubbThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
David O WaltonThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Vivek M PhilipThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Georgi KolishovskiThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Tim StearnsThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Matthew H DunnThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Daniel A SkellyThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Beena KadakkuzhaThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Gregg TeHennepeThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Govindarajan Kunde-RamamoorthyThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Elissa J CheslerThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Phenome ProjectR01DA028420 · NIDA · JACKSON LABORATORY · PI Elissa J Chesler · 2010 to 2026
$9.5M
Discovery of Addiction-Related Genes with Advanced Mouse ResourcesR01DA037927 · NIDA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2015 to 2025
$8.1M
CRCNS: Computational Approach to Assess Replicability of Neurobehavior Phenotypes R01DA045401 · NIDA · JACKSON LABORATORY · PI BOGUE, MOLLY A · 2017 to 2019
$760k
NCI NIH HHS P30 CA034196NIDA NIH HHS R01 DA028420NIDA NIH HHS R01 DA037927NIDA NIH HHS R01 DA045401
6 · The paper itself

Abstract

The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API. MPD provides rigorous curation of experimental data and supporting documentation using relevant ontologies and controlled vocabularies. Most data in MPD are from inbreds and other reproducible strains such that the data are cumulative over time and across laboratories. The resource has been expanded to include the QTL Archive and other primary phenotype data from mapping crosses as well as advanced high-diversity mouse populations including the Collaborative Cross and Diversity Outbred mice. Furthermore, MPD provides a means of assessing replicability and reproducibility across experimental conditions and protocols, benchmarking assays in users' own laboratories, identifying sensitized backgrounds for making new mouse models with genome editing technologies, analyzing trait co-inheritance, finding the common genetic basis for multiple traits and assessing sex differences and sex-by-genotype interactions.

Indexed as

Databases, FactualData CurationPhenotypeAnimalsDatabases, GeneticData DisplayFemaleGene EditingGenetic Association StudiesGenetic VariationMaleMiceMice, Inbred StrainsMice, Mutant StrainsReproducibility of ResultsSex Characteristics

Identifiers

PMID29136208
PMCPMC5753241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.