ArticleGenome biology and evolution2017
RAD-Seq Reveals Patterns of Additive Polygenic Variation Caused by Spatially-Varying Selection in the American Eel (Anguilla rostrata).
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Putatively Adaptive and Genome-Wide Genetic Variation Often Rank Populations as Similarly Distinctive.Molecular ecology · 2026Article
- Genomic Footprints of Hybridisation in North Atlantic Eels (Anguilla anguilla and A. rostrata).Molecular ecology · 2025Article
- Genomic Signals of Local Adaptation Associated With Environmental Variables inEcology and evolution · 2025Article
- DNA methylation patterns linked to salinity and geography in the American eel (Environmental epigenetics · 2025Article
- Eels' individual migratory behavior stems from a complex syndrome involving cognition, behavior, physiology, and life history.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic signatures of climate adaptation in bank voles.Ecology and evolution · 2024Article
- Panmixia in the American eel extends to its tropical range of distribution: Biological implications and policymaking challenges.Evolutionary applications · 2023Article
- Neutral and adaptive loci reveal fine-scale population structure inEcology and evolution · 2022Article
- Landscape genomics of the streamside salamander: Implications for species management in the face of environmental change.Evolutionary applications · 2022Article
- Genome assembly of the roundjaw bonefish (GigaByte (Hong Kong, China) · 2022Article
- Local thermal adaptation and limited gene flow constrain future climate responses of a marine ecosystem engineer.Evolutionary applications · 2020Article
- Insights into the neutral and adaptive processes shaping the spatial distribution of genomic variation in the economically important Moroccan locust (Ecology and evolution · 2020Article
- Article
- The conundrum of species delimitation: a genomic perspective on a mitogenetically super-variable butterfly.Proceedings. Biological sciences · 2019Article
- Evolutionary Toxicogenomics of the Striped Killifish (International journal of molecular sciences · 2019Article
- Seascape genomics of eastern oyster (Evolutionary applications · 2019Article
- Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications.International journal of nanomedicine · 2019Review
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- Comparison of Migratory and Resident Populations of Brown Trout Reveals Candidate Genes for Migration Tendency.Genome biology and evolution · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The American Eel (Anguilla rostrata) has an exceptional life cycle characterized by panmictic reproduction at the species scale, random dispersal, and selection in a highly heterogeneous habitat extending from subtropical to subarctic latitudes. The genetic consequences of spatially-varying selection in this species have been investigated for decades, revealing subtle clines in allele frequency at a few loci that contrast with complete panmixia on the vast majority of the genome. Because reproduction homogenizes allele frequencies every generation, sampling size, and genomic coverage are critical to reach sufficient power to detect selected loci in this context. Here, we used a total of 710 individuals from 12 sites and 12,098 high-quality single nucleotide polymorphisms to re-evaluate the extent to which local selection affects the spatial distribution of genetic diversity in this species. We used environmental association methods to identify markers under spatially-varying selection, which indicated that selection affects ∼1.5% of the genome. We then evaluated the extent to which candidate markers collectively vary with environmental factors using additive polygenic scores. We found significant correlations between polygenic scores and latitude, longitude and temperature which are consistent with polygenic selection acting against maladapted genotypes in different habitats occupied by eels throughout their range of distribution. Gene functions associated with outlier markers were significantly enriched for the insulin signaling pathway, indicating that the trade-offs inherent to occupying such a large distribution range involve the regulation of metabolism. Overall, this study highlights the potential of the additive polygenic scores approach in detecting selective effects in a complex environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.