ArticleCerebral cortex (New York, N.Y. : 1991)2018
Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on the quantitative relationship between structural and functional network connectivity strength in mammalian brains.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Combining phase analysis and causal stimulation enables longitudinal mesoscale connectivity mapping.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.Science advances · 2026Article
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Mapping functional connectivity in the pigeon brain with wide-field optical imaging.Neurophotonics · 2026Article
- Psychedelic 5-HTNature neuroscience · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Cerebral blood flow patterns induced by photoactivation based on laser speckle contrast imaging.Biomedical optics express · 2024Article
- Claustrum modulation drives altered prefrontal cortex dynamics and connectivity.Communications biology · 2024Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice.GeroScience · 2024Article
- Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.Brain : a journal of neurology · 2024Article
- Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Cortical connectivity is embedded in resting state at columnar resolution.Progress in neurobiology · 2022Article
- A Multivariate Functional Connectivity Approach to Mapping Brain Networks and Imputing Neural Activity in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
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11 authors.
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Abstract
Brain connectomics has expanded from histological assessment of axonal projection connectivity (APC) to encompass resting state functional connectivity (RS-FC). RS-FC analyses are efficient for whole-brain mapping, but attempts to explain aspects of RS-FC (e.g., interhemispheric RS-FC) based on APC have been only partially successful. Neuroimaging with hemoglobin alone lacks specificity for determining how activity in a population of cells contributes to RS-FC. Wide-field mapping of optogenetically defined connectivity could provide insights into the brain's structure-function relationship. We combined optogenetics with optical intrinsic signal imaging to create an efficient, optogenetic effective connectivity (Opto-EC) mapping assay. We examined EC patterns of excitatory neurons in awake, Thy1-ChR2 transgenic mice. These Thy1-based EC (Thy1-EC) patterns were evaluated against RS-FC over the cortex. Compared to RS-FC, Thy1-EC exhibited increased spatial specificity, reduced interhemispheric connectivity in regions with strong RS-FC, and appreciable connection strength asymmetry. Comparing the topography of Thy1-EC and RS-FC patterns to maps of APC revealed that Thy1-EC more closely resembled APC than did RS-FC. The more general method of Opto-EC mapping with hemoglobin can be determined for 100 sites in single animals in under an hour, and is amenable to other neuroimaging modalities. Opto-EC mapping represents a powerful strategy for examining evolving connectivity-related circuit plasticity.
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