ArticleCerebral cortex (New York, N.Y. : 1991)2018
Local and Global Spatial Organization of Interaural Level Difference and Frequency Preferences in Auditory Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Population decoding of sound source location by receptive field neurons in the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex.iScience · 2025Article
- Learning spatial hearing via innate mechanisms.PLoS computational biology · 2025Article
- Article
- Distinct Neuron Types Contribute to Hybrid Auditory Spatial Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues.bioRxiv : the preprint server for biology · 2024Article
- Auditory cortex conveys non-topographic sound localization signals to visual cortex.Nature communications · 2024Article
- Fractured columnar small-world functional network organization in volumes of L2/3 of mouse auditory cortex.PNAS nexus · 2024Article
- Layers 3 and 4 Neurons of the Bilateral Whisker-Barrel Cortex.Neuroscience · 2022Article
- A silent two-photon imaging system for studying in vivo auditory neuronal functions.Light, science & applications · 2022Article
- AIM: A network model of attention in auditory cortex.PLoS computational biology · 2021Article
- Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex.Frontiers in neuroscience · 2021Article
- Functional organization of mouse primary auditory cortex in adult C57BL/6 and F1 (CBAxC57) mice.Scientific reports · 2020Article
- Article
- Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The Influence of Inhibition of Return and Level-Priming on the Global Precedence Effect.Computational intelligence and neuroscience · 2020Article
- Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences.Journal of neurophysiology · 2019Article
- Neural encoding of sensory and behavioral complexity in the auditory cortex.Current opinion in neurobiology · 2018Review
- Contrast gain control in mouse auditory cortex.Journal of neurophysiology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Despite decades of microelectrode recordings, fundamental questions remain about how auditory cortex represents sound-source location. Here, we used in vivo 2-photon calcium imaging to measure the sensitivity of layer II/III neurons in mouse primary auditory cortex (A1) to interaural level differences (ILDs), the principal spatial cue in this species. Although most ILD-sensitive neurons preferred ILDs favoring the contralateral ear, neurons with either midline or ipsilateral preferences were also present. An opponent-channel decoder accurately classified ILDs using the difference in responses between populations of neurons that preferred contralateral-ear-greater and ipsilateral-ear-greater stimuli. We also examined the spatial organization of binaural tuning properties across the imaged neurons with unprecedented resolution. Neurons driven exclusively by contralateral ear stimuli or by binaural stimulation occasionally formed local clusters, but their binaural categories and ILD preferences were not spatially organized on a more global scale. In contrast, the sound frequency preferences of most neurons within local cortical regions fell within a restricted frequency range, and a tonotopic gradient was observed across the cortical surface of individual mice. These results indicate that the representation of ILDs in mouse A1 is comparable to that of most other mammalian species, and appears to lack systematic or consistent spatial order.
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