ArticlePloS one2017
Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- The influence of uterine fibroids on adverse outcomes in pregnant women: a meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- The risk of preterm birth in women with uterine fibroids: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Uterine fibroids detected in early pregnancy and their association with adverse pregnancy outcomes: a single-centre retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Proactive Management of Gestational Hypertension in a Patient With Uterine Fibroids: A Case Report.Clinical case reports · 2026Article
- Management of atypical complicated abdominal masses in the second trimester of pregnancy.BMJ case reports · 2026Article
- Influence of uterine fibroid size on perinatal and neonatal outcomes: a single-centre cohort of 651 pregnancies.BMC pediatrics · 2025Article
- The epidemiology of uterine fibroids: global disease burden from 1990 to 2021 and future trend predictions.Frontiers in reproductive health · 2025Article
- Uterine artery doppler and pregnancy-associated plasma protein-A in pregnancies with fibroids.Clinics (Sao Paulo, Brazil) · 2025Article
- Antepartum risk factors and outcomes of massive transfusion for elective cesarean section: a nationwide retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Article
- Uterine fibroids & infertility: which fibroids should be removed?-a narrative review.Gynecology and pelvic medicine · 2024Review
- Long-term obstetric, perinatal, and surgical complications in singleton pregnancies following previous cesarean myomectomy: a retrospective multicentric study.Frontiers in surgery · 2024Article
- Article
- Pregnancy With Uterine Fibroids: Obstetric Outcome at a Tertiary Care Hospital of Central India.Cureus · 2023Article
- Uterine Fibroids and Pregnancy: How Do They Affect Each Other?Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Uterine fibroids in pregnancy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Uterine fibroids increase the risk of preterm birth and other adverse birth events: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Pregnancy outcomes among women with endometriosis and fibroids: registry linkage study in Massachusetts.American journal of obstetrics and gynecology · 2022Article
- Increased Expression of Fibroblast Activation Protein is Associated with Autophagy Dysregulation and Oxidative Stress in Obese Women with Uterine Fibroids.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Effects of total laparoscopic hysterectomy on the clinical outcomes of patients with uterine fibroids.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the association between uterine fibroids and adverse obstetric outcomes.
methodsThis was a retrospective cross-sectional study of 112,403 deliveries from 14 provinces and 39 different hospitals in 2011 in mainland China. We compared pregnancy outcomes in women with and without uterine fibroids who underwent detailed second trimester obstetric ultrasonography during 18 to 22 weeks. Obstetric outcomes include cesarean delivery, breech presentation, preterm delivery, placenta previa, placental abruption, premature rupture of membranes and neonatal birthweight. Univariate analyses and multivariate logistic regression analyses were performed.
resultsOf 112,403 women who underwent routine obstetric survey, 3,012 (2.68%) women were identified with at least 1 fibroid. By univariate and multivariate analyses, the presence of uterine fibroids was significantly associated with cesarean delivery (Adjusted odds radio [AOR] 1.8, 95% confidence interval [CI] 1.7-2.0), breech presentation (AOR 1.3, 95% CI 1.2-1.5) and postpartum hemorrhage (AOR 1.2, 95% CI 1.1-1.4). The size of uterine fibroids and location in uterus had important effect on the mode of delivery. The rates of PPH were significantly higher with increasing size of the uterine fibroid (P<0.001). And the location of fibroid (intramural, submucosal or subserosal) also have a statistically significant impact on the risk of PPH (5.6% [subserosal] vs 4.7% [submucosal] vs 8.6% [intramural]).
conclusionPregnant women with uterine fibroids are at increased risk for cesarean delivery, breech presentation and postpartum hemorrhage. And different characteristics of uterine fibroids affect obstetric outcomes through different ways. Such detailed information may be useful in risk-stratifying pregnant women with fibroids.
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Registered trials
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