ArticlePLoS biology2017
Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.Molecular and cellular biology · 2021Article
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- Protein assembly systems in natural and synthetic biology.BMC biology · 2020Review
- A white-to-opaque-like phenotypic switch in the yeast Torulaspora microellipsoides.Communications biology · 2020Article
- Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans.PLoS genetics · 2019Article
- The causes of evolvability and their evolution.Nature reviews. Genetics · 2019Review
- More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.Journal of molecular biology · 2018Review
- Abandoning the ship using sex, dispersal or dormancy: multiple escape routes from challenging conditions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- A brief overview of the Swi1 prion-[SWI+].FEMS yeast research · 2018Review
- Microbial specialization by prions.Prion · 2018Article
- Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast.PLoS biology · 2017Article
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2 authors.
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Abstract
To thrive in an ever-changing environment, microbes must widely distribute their progeny to colonize new territory. Simultaneously, they must evolve and adapt to the stresses of unpredictable surroundings. In both of these regards, diversity is key-if an entire population moved together or responded to the environment in the same way, it could easily go extinct. Here, we show that the epigenetic prion switch [SWI+] establishes a specialized subpopulation with a "pioneer" phenotypic program in Saccharomyces cerevisiae. Cells in the pioneer state readily disperse in water, enabling them to migrate and colonize new territory. Pioneers are also more likely to find and mate with genetically diverse partners, as inhibited mating-type switching causes mother cells to shun their own daughters. In the nonprion [swi-] state, cells instead have a "settler" phenotype, forming protective flocs and tending to remain in their current position. Settler cells are better able to withstand harsh conditions like drought and alkaline pH. We propose that these laboratory observations reveal a strategy employed in the wild to rapidly diversify and grant distinct, useful roles to cellular subpopulations that benefit the population as a whole.
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