Evidence map›Paper›PMID 29135976›Full record

ArticlePediatric research2017

Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.

Deepti Narla, Stacey B Slagle, Caitlin M Schaefer, Daniel S Bushnell, Pawan Puri, Carlton M Bates

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Deepti NarlaAkron Children's Hospital, Akron, Ohio.
Stacey B SlagleDepartment of Pediatrics, The Women's Hospital, Newburgh, Indiana.
Caitlin M SchaeferDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Daniel S BushnellDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Pawan PuriDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Carlton M BatesDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
University of Pittsburgh · USAkron Children's Hospital · USWomen's Hospital · US

Funding

TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE · 2005 to 2026
$26.6M
Research Training & Career Development ProgramU54CA118638 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI Desiree Avia Rivers · 2005 to 2026
$22.7M
Research Education CoreU54CA118623 · NCI · TUSKEGEE UNIVERSITY · PI Vivian L Carter, TIMOTHY TURNER · 2005 to 2026
$20.2M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2008 to 2022
$13.4M
INFRASTRUCTURE IIG12MD007585 · NIMHD · TUSKEGEE UNIVERSITY · PI YATES, CLAYTON · 2012 to 2016
$4.6M
Research Training in Pediatric NephrologyT32DK091202 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATES, CARLTON MATTHEW · 2011 to 2020
$2.2M
Critical Roles for Fibroblast Growth Factor Receptors in Bladder DevelopmentR01DK104374 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATES, CARLTON MATTHEW · 2015 to 2018
$1.4M
NCI NIH HHS U54 CA118623NCI NIH HHS U54 CA118638NCI NIH HHS U54 CA118948NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK104374NIDDK NIH HHS T32 DK091202NIMHD NIH HHS G12 MD007585
6 · The paper itself

Abstract

BackgroundFibroblast growth factor receptor 2 (Fgfr2) deletion from murine peri-Wolffian duct stroma (ST) results in aberrant ureteric bud induction, abnormal ureteral insertion into the bladder, and high rates of vesicoureteral reflux (VUR). It is unclear which receptor docking protein(s) is/are responsible for Fgfr2 actions in these tissues. We investigated whether the docking protein, fibroblast receptor substrate 2α (Frs2α), had a role in peri-Wolffian duct ST similar to Fgfr2.MethodsWe conditionally deleted Frs2α in peri-Wolffian duct ST with a Tbx18cre mouse line (Frs2α CONTROLS: Mutant refluxing ureters that inserted improperly into the bladder had shortened intravesicular tunnels (IVTs) when compared with controlsConclusionFrs2α

Indexed as

AnimalsApoptosisBone Morphogenetic Protein 4Cell ProliferationMembrane ProteinsMiceMice, KnockoutUreterVesico-Ureteral RefluxWolffian DuctsBmp4 protein, mouseBone Morphogenetic Protein 4FRS2alpha protein, mouseMembrane Proteins

Identifiers

PMID29135976
PMCPMC5701656
OpenAlexW2738476697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.