ArticleThe ISME journal2018
Metabolic shift at the class level sheds light on adaptation of methanogens to oxidative environments.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 116 citations in OpenAlex.
- Methanogens: vital but threatened members of the human microbiome?Trends in microbiology · 2026Review
- Proteome-informed interrogation of a methanogenic archaeon links stress response mechanisms with microbial performance and robustness during biomethanation.Engineering microbiology · 2026Article
- Article
- Reduced methane emissions in transgenic rice genotypes are associated with altered rhizosphere microbial hydrogen cycling.Nature communications · 2026Article
- Nitrate reduction salvage pathway inFrontiers in microbiology · 2026Article
- Cultivation and genomic characterization of novel methanogens from arid desert biocrust.ISME communications · 2026Article
- Identification of microbial groups and functional genes associated with greenhouse gas emissions in prawn farms.Scientific reports · 2025Article
- Aldehyde dehydrogenase activity is induced by oxygen exposure in the anaerobic archaeon Methanosarcina acetivorans.World journal of microbiology & biotechnology · 2025Article
- Micro-aeration for improving anaerobic treatment and biogas production from organic pollutants.Applied microbiology and biotechnology · 2025Review
- Exploring methanogenic archaea and their thermal responses in the glacier-fed stream sediments of Rongbuk River basin, Mt. Everest.FEMS microbiology ecology · 2025Article
- Cometabolism of ferrihydrite reduction and methyl-dismutating methanogenesis byApplied and environmental microbiology · 2025Article
- Comparative assessment of a restored and natural wetland usingApplied and environmental microbiology · 2025Article
- Uncovering dynamic transcriptional regulation of methanogenesis via single-cell imaging of archaeal gene expression.Nature communications · 2025Article
- Oxidative adaptations in prokaryotes imply the oxygenic photosynthesis before crown-groupPNAS nexus · 2025Article
- Coastal methane emissions driven by aerotolerant methanogens using seaweed and seagrass metabolites.Nature geoscience · 2025Article
- Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics.Microbiome · 2024Article
- Impact of mineral and non-mineral sources of iron and sulfur on the metalloproteome ofApplied and environmental microbiology · 2024Article
- The Selenoproteome as a Dynamic Response Mechanism to Oxidative Stress in Hydrogenotrophic Methanogenic Communities.Environmental science & technology · 2024Article
- Uranium Biogeochemistry in the Rhizosphere of a Contaminated Wetland.Environmental science & technology · 2024Article
- Effect of micro-aeration on syntrophic and methanogenic activity in anaerobic sludge.Applied microbiology and biotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanogens have long been considered strictly anaerobic and oxygen-sensitive microorganisms, but their ability to survive oxygen stress has also been documented. Indeed, methanogens have been found in oxidative environments, and antioxidant genes have been detected in their genomes. How methanogens adapt to oxidative environments, however, remain poorly understood. Here, we systematically predicted and annotated antioxidant features from representative genomes across six well-established methanogen orders. Based on functional gene content involved in production of reactive oxygen species, Hierarchical Clustering analyses grouped methanogens into two distinct clusters, corresponding to the Class I and II methanogens, respectively. Comparative genomics suggested a systematic shift in metabolisms across the two classes, resulting in an enrichment of antioxidant features in the Class II. Moreover, meta-analysis of 16 S rRNA gene sequences obtained from EnvDB indicated that members of Class II were more frequently recovered from microaerophilic and even oxic environments than the Class I members. Phylogenomic analysis suggested that the Class I and II methanogens might have evolved before and around the Great Oxygenation Event, respectively. The enrichment of antioxidant features in the Class II methanogens may have played a key role in the adaption of this group to oxidative environments today and historically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.