ArticlePlastic and reconstructive surgery2018
Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention.
Article in Plastic and reconstructive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Optimization of fat grafting to attenuate radiation damage: a narrative review.Gland surgery · 2026Review
- Deferoxamine Improves Radiation-Induced Peripheral Neuropathy.Journal of cellular and molecular medicine · 2026Article
- Divergent effects of topical deferoxamine treatment on skin and cancer cells uncovers its potential as a safe radioprotective agent in oncological applications.Cancer cell international · 2026Article
- Improving Fat Graft Survival Using Soluble Molecule Preconditioning.Biomolecules · 2025Review
- Hypoxic microenvironment promotes diabetic wound healing by polarizing macrophages to the M2 phenotype in vivo.Journal of molecular histology · 2024Article
- Role of ferroptosis in radiation-induced soft tissue injury.Cell death discovery · 2024Review
- Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis.Advances in wound care · 2024Review
- Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin.Journal of cellular and molecular medicine · 2024Article
- Exploratory Analysis of Image-Guided Ionizing Radiation Delivery to Induce Long-Term Iron Accumulation and Ferritin Expression in a Lung Injury Model: Preliminary Results.Bioengineering (Basel, Switzerland) · 2024Article
- Effects of microenvironment and biological behavior on the paracrine function of stem cells.Genes & diseases · 2024Review
- The Influence of Different Irradiation Regimens on Inflammation and Vascularization in a Random-Pattern Flap Model.Journal of personalized medicine · 2023Article
- Chelating the valley of death: Deferoxamine's path from bench to wound clinic.Frontiers in medicine · 2023Article
- Mechanical Stress Improves Fat Graft Survival by Promoting Adipose-Derived Stem Cells Proliferation.International journal of molecular sciences · 2022Article
- Deferoxamine to Minimize Fibrosis During Radiation Therapy.Advances in wound care · 2022Article
- Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review.Journal of reconstructive microsurgery · 2022Review
- Decellularized Adipose Matrices Can Alleviate Radiation-Induced Skin Fibrosis.Advances in wound care · 2022Article
- Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis.Aesthetic surgery journal · 2022Article
- Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin.Journal of translational medicine · 2022Article
- "Fasting: An Effective Preconditioning Method to Increase Fat Graft Survival".Aesthetic plastic surgery · 2022Article
- Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study.Frontiers in medicine · 2022Article
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundRadiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve the quality of irradiated skin, but volume retention of the graft is significantly decreased. Deferoxamine is a U.S. Food and Drug Administration-approved iron-chelating medication for acute iron intoxication and chronic iron overload that has also been shown to increase angiogenesis. The present study evaluates the effects of deferoxamine treatment on irradiated skin and subsequent fat graft volume retention.
methodsMice underwent irradiation to the scalp followed by treatment with deferoxamine or saline and perfusion and were analyzed using laser Doppler analysis. Human fat grafts were then placed beneath the scalp and retention was also followed up to 8 weeks radiographically. Finally, histologic evaluation of overlying skin was performed to evaluate the effects of deferoxamine preconditioning.
resultsTreatment with deferoxamine resulted in significantly increased perfusion, as demonstrated by laser Doppler analysis and CD31 immunofluorescent staining (p < 0.05). Increased dermal thickness and collagen content secondary to irradiation, however, were not affected by deferoxamine (p > 0.05). Importantly, fat graft volume retention was significantly increased when the irradiated recipient site was preconditioned with deferoxamine (p < 0.05).
conclusionsThe authors' results demonstrated increased perfusion with deferoxamine treatment, which was also associated with improved fat graft volume retention. Preconditioning with deferoxamine may thus enhance fat graft outcomes for soft-tissue reconstruction following radiation therapy.
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