ArticleCornea2018
Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.
Article in Cornea, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Transforming corneal alkali burn treatment: unveiling mechanisms and pioneering therapies from bench to bedside.Journal of translational medicine · 2025Review
- Article
- The prophylactic value of TNF-α inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma.Acta ophthalmologica · 2024Article
- Sustained Inhibition of VEGF and TNF-α Achieves Multi-Ocular Protection and Prevents Formation of Blood Vessels after Severe Ocular Trauma.Pharmaceutics · 2023Article
- Novel micellar CB2 receptor agonist with anti-inflammatory action for treating corneal alkali burns in a mouse model.Frontiers in pharmacology · 2023Article
- Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn.International journal of molecular sciences · 2022Article
- Th17 Activation and Th17/Treg Imbalance in Prolonged Anterior Intraocular Inflammation after Ocular Alkali Burn.International journal of molecular sciences · 2022Article
- Inhibition of endoplasmic reticulum stress by 4-phenylbutyrate alleviates retinal inflammation and the apoptosis of retinal ganglion cells after ocular alkali burn in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- The Epidemiology of Chemical Burns Among the Patients Referred to Burn Centers in Shiraz, Southern Iran, 2008-2018.Bulletin of emergency and trauma · 2021Article
- Intrinsic Optical Properties of Boston Keratoprosthesis.Translational vision science & technology · 2020Article
- Glaucoma after Ocular Surgery or Trauma: The Role of Infiltrating Monocytes and Their Response to Cytokine Inhibitors.The American journal of pathology · 2020Article
- Treatment of Oculoplastic and Ocular Surface Disease in Eyes Implanted with a Type I Boston Keratoprosthesis in Southern China: A Retrospective Study.Advances in therapy · 2020Article
- Glaucoma after ocular chemical burns: Incidence, risk factors, and outcome.Scientific reports · 2020Article
- Correlation analysis of the clinical features and prognosis of acute ocular burns-exploration of a new classification scheme.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Glaucoma After Corneal Trauma or Surgery-A Rapid, Inflammatory, IOP-Independent Pathway.Cornea · 2019Article
- RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury.The American journal of pathology · 2018Article
- Management of glaucoma with Boston type 1 keratoprosthesis.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
31 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases.
methodsRecent laboratory and clinical data on the biology and treatment of chemical burns are analyzed.
resultsCorneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells. Prompt anti-TNF-α treatment is markedly neuroprotective. Long term profound reduction of the intraocular pressure is also vital.
conclusionA new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.