Evidence map›Paper›PMID 29135581›Full record

ArticleAIDS (London, England)2018

High rates of hypertension, diabetes, elevated low-density lipoprotein cholesterol, and cardiovascular disease risk factors in HIV-infected patients in Malawi.

Sekai C Mathabire Rücker, Alia Tayea, Joseph Bitilinyu-Bangoh, Elkin H Bermúdez-Aza, Leon Salumu, Isabel Amoros Quiles, Elisabeth Szumilin, Zengani Chirwa, Fernanda Rick, David Maman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 6 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Sekai C Mathabire RückerMédecins Sans Frontières, Chiradzulu.
Alia TayeaMédecins Sans Frontières, Chiradzulu.
Joseph Bitilinyu-BangohQueen Elizabeth Central Hospital, Blantyre, Malawi.
Elkin H Bermúdez-AzaMédecins Sans Frontières, Chiradzulu.
Leon SalumuMédecins sans Frontières, Paris, France.
Isabel Amoros QuilesMédecins sans Frontières, Lilongwe.
Elisabeth SzumilinMédecins sans Frontières, Paris, France.
Zengani ChirwaHIV and AIDS Department, Ministry of Health Malawi, Lilongwe, Malawi.
Fernanda RickMédecins Sans Frontières, Chiradzulu.
David MamanEpicentre, Paris, France.
Médecins Sans Frontières · UGMédecins Sans Frontières · FRPublic Health Institute of Malawi · MWQueen Elizabeth Central Hospital · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesData on cardiovascular disease risks among HIV-infected patients taking antiretroviral therapy (ART) over long periods of time are lacking in Sub-Saharan Africa.

methodsA cross-sectional study was conducted in Chiradzulu, Malawi from December 2015 to June 2016. HIV-infected persons on ART for more than 10 years (patients) and HIV-negative individuals (controls) from selected clinics participated. Following informed consent, a standardized questionnaire, clinical and laboratory examinations were performed. The prevalence of cardiovascular disease risk factors was calculated and stratified by age group.

resultsOverall, 379 HIV-infected patients and 356 controls participated. Median time on ART among patients was 11.6 years (interquartile range 10.6-12.4).Within the 30-44, 45-59, and at least 60-year age groups, respectively, the prevalence of hypertension was 10.8, 20.4, and 44.7% among patients and 6.1, 25.8, and 42.9% among controls. Hypertension was previously undiagnosed in 60.3% patients and 37.0% controls with elevated blood pressure. The prevalence of diabetes within the respective age groups was 5.0, 6.4, and 13.2% among patients, and 3.4, 4.2, and 1.7% among controls. HIV-infected patients were more likely to have an glycated hemoglobin at least 6.0% (adjusted odds ratio 1.9; 95% confidence interval 1.1-3.2, P = 0.02). Prevalence of low-density lipoprotein cholesterol more than 130 mg/dl within the respective age groups was 8.0, 15.4, and 23.7% among patients and 1.8, 12.5, and 11.8% among controls.

conclusionNoncommunicable diseases were a significant burden in Malawi, with high prevalence of hypercholesterolemia in all survey participants and an especially acute diabetes burden among older HIV infected. Hypertension screening and treatment services are needed among identified high-risk groups to cover unmet needs.

Indexed as

AdultCardiovascular DiseasesCholesterol, LDLCross-Sectional StudiesDiabetes MellitusFemaleHIV InfectionsHumansHypercholesterolemiaHypertensionMalawiMaleMiddle AgedPrevalenceRisk FactorsCholesterol, LDL

Identifiers

PMID29135581
PMCPMC5757671
OpenAlexW2911390988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.