Evidence map›Paper›PMID 29135382›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities.

Gaia Rizzo, Mattia Veronese, Matteo Tonietto, Benedetta Bodini, Bruno Stankoff, Catriona Wimberley, Sonia Lavisse, Michel Bottlaender, Peter S Bloomfield, Oliver Howes and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.European journal of nuclear medicine and molecular imaging · 2023
    Pooled it
  2. Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  11. [European journal of nuclear medicine and molecular imaging · 2023
    Article
  12. Innate immune cells and myelin profile in multiple sclerosis: a multi-tracer PET/MR study.European journal of nuclear medicine and molecular imaging · 2022
    Article
  13. Supervised clustering for TSPO PET imaging.European journal of nuclear medicine and molecular imaging · 2021
    Review
  14. Radiosynthesis and characterization of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  15. What value can TSPO PET bring for epilepsy treatment?European journal of nuclear medicine and molecular imaging · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gaia Rizzo1 Department of Information Engineering, Padova University, Padova, Italy.ORCID 0000-0001-7272-8576
Mattia Veronese2 Department of Neuroimaging, King's College London, London, UK.
Matteo Tonietto3 UPMC, Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, Paris, France.
Benedetta Bodini3 UPMC, Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, Paris, France.
Bruno Stankoff3 UPMC, Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, Paris, France.
Catriona Wimberley5 IMIV, Inserm, CEA, Paris-Sud Univ, Université Paris Saclay, Orsay, France.
Sonia Lavisse6 Département de Recherche Fondamentale (DRF), Institut d'Imagerie Biomédicale (I2BM), Fontenay-aux-Roses, France.
Michel Bottlaender5 IMIV, Inserm, CEA, Paris-Sud Univ, Université Paris Saclay, Orsay, France.
Peter S Bloomfield9 Institute of Clinical Sciences, Imperial College London, London, UK.
Oliver Howes9 Institute of Clinical Sciences, Imperial College London, London, UK.
Paolo Zanotti-Fregonara11 Houston Methodist Hospital, PET Core Facility, Research Institute, Stanley H. Appel Department of Neurology, Houston, Texas, USA.
Federico E Turkheimer2 Department of Neuroimaging, King's College London, London, UK.
Alessandra Bertoldo1 Department of Information Engineering, Padova University, Padova, Italy.

Funding

Department of HealthMedical Research Council G0700995Medical Research Council G0900891Medical Research Council G1100809Medical Research Council MC-A656-5QD30Medical Research Council MC_U120085814Medical Research Council MC_U120097115Medical Research Council MR/K022733/1Wellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main target of positron emission tomography (PET) ligands for neuroinflammation. Previous works showed that accounting for TSPO endothelial binding improves PET quantification for [

Indexed as

Carbon RadioisotopesEndothelial CellsGray MatterHumansKineticsLigandsModels, BiologicalPositron-Emission TomographyPyrazolesPyrimidinesReceptors, GABAWhite MatterCarbon RadioisotopesLigandsN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptors, GABATSPO protein, humanclustering[C]PBR28[C]-R-PK11195endothelium[F]DPA714kinetic modellingmicroglianeuroinflammationreference regionTranslocator protein

Identifiers

PMID29135382
PMCPMC6501510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.