Evidence map›Paper›PMID 29134797›Full record

ArticleACS infectious diseases2018

The Importance of Collaboration between Industry, Academics, and Nonprofits in Tropical Disease Drug Discovery.

Lori Ferrins, Michael P Pollastri

Abstract read
In one paragraph

Article in ACS infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. An Updated View of theACS infectious diseases · 2022
    Review
  8. Identification of β-Lactams Active againstACS infectious diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lori FerrinsDepartment of Chemistry & Chemical Biology , Northeastern University , Hurtig 102, 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.ORCID 0000-0001-8992-0919
Michael P PollastriDepartment of Chemistry & Chemical Biology , Northeastern University , Hurtig 102, 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.ORCID 0000-0001-9943-7197

Funding

Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead DrugR01AI124046 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI, MENSA-WILMOT, KOJO A. · 2016 to 2025
$6.0M
Repurposing human kinase inhibitor chemotypes for Neglected Tropical DiseasesR01AI114685 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI · 2015 to 2025
$4.6M
Lead optimization of agents targeting multiple kinetoplastid parasitesR21AI127594 · NIAID · NORTHEASTERN UNIVERSITY · PI POLLASTRI, MICHAEL P · 2017 to 2018
$427k
NIAID NIH HHS R01 AI114685NIAID NIH HHS R01 AI124046NIAID NIH HHS R21 AI127594
6 · The paper itself

Abstract

Collaborations between academic, industrial, and nonprofit companies can provide sufficient impetus to propel projects that have little economic return; such projects are prevalent in tropical disease drug discovery. In these collaborations, each partner contributes a unique set of skills and technical expertise which is advantageous to the project as a whole. Highly product-focused processes and specialized expertise sets dominate industry groups. When coupled with the strategic guidance from public-private partnerships and the academic tendency to work on high-risk projects with low financial rewards, a powerful combination results. There are numerous examples throughout the literature about these collaborative efforts to combat a variety of tropical diseases (including leishmaniasis, Chagas disease, African sleeping sickness, and malaria), from all stages of the drug discovery process to the advancement of new drugs into the clinic. However, there is still uncertainty from many academic institutions as to how to establish and engage in these research consortiums. This Viewpoint highlights opportunities, benefits, and suggestions for productive collaborations in this disease space.

Indexed as

Intersectoral CollaborationPublic-Private Sector PartnershipsAnti-Infective AgentsCommunicable DiseasesDrug DiscoveryHumansAnti-Infective Agents

Identifiers

PMID29134797
PMCPMC6584757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.