Evidence map›Paper›PMID 29134784›Full record

ArticleAngewandte Chemie (International ed. in English)2017

A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging.

Wei Chen, Shi Xu, Jacob J Day, Difei Wang, Ming Xian

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. 1,4-Dihydropyrrolo[3,2-Organic chemistry frontiers : an international journal of organic chemistry · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. A modular template for the design of thiol-triggered sensors and prodrugs.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei ChenDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.
Shi XuDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.
Jacob J DayDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.
Difei WangDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, 20850, USA.
Ming XianDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA.ORCID 0000-0002-7902-2987

Funding

Novel Sulfide Releasing Agents for Ischemic InjuryR01HL116571 · NHLBI · WASHINGTON STATE UNIVERSITY · PI LEFER, DAVID JOSEPH, XIAN, MING · 2014 to 2017
$1.8M
Novel Sulfur Dioxide Donors and Their Cardioprotective EffectsF31HL137233 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DAY, JACOB J · 2017 to 2018
$71k
NHLBI NIH HHS F31 HL137233NHLBI NIH HHS R01 HL116571
6 · The paper itself

Abstract

Near-infrared (NIR) fluorescent dyes with favorable photophysical properties are highly useful for bioimaging, but such dyes are still rare. The development of a unique class of NIR dyes via modifying the rhodol scaffold with fused tetrahydroquinoxaline rings is described. These new dyes showed large Stokes shifts (>110 nm). Among them, WR3, WR4, WR5, and WR6 displayed high fluorescence quantum yields and excellent photostability in aqueous solutions. Moreover, their fluorescence properties were tunable by easy modifications on the phenolic hydroxy group. Based on WR6, two NIR fluorescent turn-on probes, WSP-NIR and SeSP-NIR, were devised for the detection of H

Indexed as

Spectroscopy, Near-InfraredFluorescent DyesHeLa CellsHumansHydrogen-Ion ConcentrationHydrogen SulfideMicroscopy, FluorescenceXanthonesFluorescent DyesHydrogen SulfiderhodolXanthonescyclizationfluorescencefluorescent probesimaging agentssulfide

Identifiers

PMID29134784
PMCPMC5773255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.