Evidence map›Paper›PMID 29134771›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2018

Detection of β-Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease.

Seyedmehdi Hossaini Nasr, Hovig Kouyoumdjian, Christiane Mallett, Sherif Ramadan, David C Zhu, Erik M Shapiro, Xuefei Huang

Open access · greenAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Photolytic disruption of Alzheimer's amyloid AβCommunications chemistry · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. MRI Contrast Agents in Glycobiology.Molecules (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Neurotheranostics as personalized medicines.Advanced drug delivery reviews · 2019
    Review
  15. Article
  16. Nanomaterials for Drug Delivery to the Central Nervous System.Nanomaterials (Basel, Switzerland) · 2019
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Seyedmehdi Hossaini NasrDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI, 48824, USA.
Hovig KouyoumdjianDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI, 48824, USA.
Christiane MallettDepartment of Radiology, Michigan State University, East Lansing, MI, 48824, USA.
Sherif RamadanDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI, 48824, USA.
David C ZhuDepartment of Radiology, Michigan State University, East Lansing, MI, 48824, USA.
Erik M ShapiroDepartment of Radiology, Michigan State University, East Lansing, MI, 48824, USA.
Xuefei HuangDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI, 48824, USA.ORCID 0000-0002-6468-5526
Michigan State University · USBenha University · EGYork University · CA

Funding

Homogeneous Heparan Sulfate Glycopeptides: Synthetic and Functional StudiesR01GM072667 · NIGMS · UNIVERSITY OF TOLEDO · PI HUANG, XUEFEI · 2005 to 2024
$5.1M
NIGMS NIH HHS R01 GM072667
6 · The paper itself

Abstract

The accumulation and formation of β-amyloid (Aβ) plaques in the brain are distinctive pathological hallmarks of Alzheimer's disease (AD). Designing nanoparticle (NP) contrast agents capable of binding with Aβ highly selectively can potentially facilitate early detection of AD. However, a significant obstacle is the blood brain barrier (BBB), which can preclude the entrance of NPs into the brain for Aβ binding. In this work, bovine serum albumin (BSA) coated NPs are decorated with sialic acid (NP-BSA

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBlood-Brain BarrierBrainContrast MediaDisease Models, AnimalHumansMagnetic Resonance ImagingMagnetite NanoparticlesMaleMiceMice, TransgenicN-Acetylneuraminic AcidSerum Albumin, BovineAmyloid beta-PeptidesContrast MediaMagnetite NanoparticlesN-Acetylneuraminic AcidSerum Albumin, Bovineblood brain barriermagnetic nanoparticlesmagnetic resonance imagingsialic acidβ-amyloid

Identifiers

PMID29134771
PMCPMC5773361
OpenAlexW2770938261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.