ArticleMolecular microbiology2018
Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine methyltransferase that requires only two conserved cysteine residues.
Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Nutrient-Driven Modulation of Microbial, Plant, and Rhizosphere Processes for Heavy Metal Remediation.Plants (Basel, Switzerland) · 2026Review
- The key to arsenic pollution remediation: engineering and functional effects of arsenic-resistant microorganisms.World journal of microbiology & biotechnology · 2026Review
- Impacts of arsenic contamination on plants and the role of microalgae in arsenic stress mitigation for sustainable agriculture.Biodegradation · 2026Review
- A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon ofmLife · 2025Article
- Biosensor-aided isolation of anaerobic arsenic-methylating bacteria from soil.ISME communications · 2025Article
- Soil redox status governs within-field spatial variation in microbial arsenic methylation and rice straighthead disease.The ISME journal · 2024Article
- Article
- Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.ACS central science · 2023Review
- Proteomic Analysis of Arsenic Resistance during Cyanide Assimilation byInternational journal of molecular sciences · 2023Article
- Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium.The ISME journal · 2022Article
- Glutathione Is Involved in the Reduction of Methylarsenate to Generate Antibiotic Methylarsenite in Enterobacter sp. Strain CZ-1.Applied and environmental microbiology · 2022Article
- Functional characterization of the methylarsenite-inducible arsRM operon from Noviherbaspirillum denitrificans HC18.Environmental microbiology · 2022Article
- Article
- Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects.Archives of toxicology · 2021Review
- Genomic Insight ofFrontiers in microbiology · 2021Article
- Article
- Microbial Arsenic Methylation in Soil and Uptake and Metabolism of Methylated Arsenic in Plants: A Review.International journal of environmental research and public health · 2019Review
- Sulfate-reducing bacteria and methanogens are involved in arsenic methylation and demethylation in paddy soils.The ISME journal · 2019Article
- Pathways of arsenic uptake and efflux.Environment international · 2019Review
- Speciation Analysis of Trace Arsenic, Mercury, Selenium and Antimony in Environmental and Biological Samples Based on Hyphenated Techniques.Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Arsenic (As) biomethylation is an important component of the As biogeochemical cycle that can influence As toxicity and mobility in the environment. Biomethylation of As is catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM). To date, all identified ArsM orthologs with As(III) methylation activities have four conserved cysteine residues, which are thought to be essential for As(III) methylation. Here, we isolated an As(III)-methylating bacterium, Bacillus sp. CX-1, and identified a gene encoding a S-adenosylmethionine methyltranserase termed BlArsM with low sequence similarities (≤ 39%) to other ArsMs. BlArsM has six cysteine residues (Cys10, Cys11, Cys145, Cys193, Cys195 and Cys268), three of which (Cys10, Cys145 and Cys195) align with conserved cysteine residues found in most ArsMs. BlarsM is constitutively expressed in Bacillus sp. CX-1. Heterologous expression of BlarsM conferred As(III) resistance. Purified BlArsM methylated both As(III) and methylarsenite (MAs[III]), with a final product of dimethylarsenate (DMAs[V]). When all six cysteines were individually altered to serine residues, only C145S and C195S derivatives lost the ability to methylate As(III) and MAs(III). The derivative C10S/C11S/C193S/C268S was still active. These results suggest that BlArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only two conserved cysteine residues. A model of As(III) methylation by BlArsM is proposed.
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