ArticleGlia2018
Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism.
Article in Glia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Maternal atopic conditions and autism spectrum disorder: a systematic review.European child & adolescent psychiatry · 2024Pooled it
- Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Healing from the Ocean: Targeting Shared Mechanisms in Autism and Epilepsy Using Algae-Derived Compounds.Marine drugs · 2026Review
- Early-life internalizing behavioral trajectories and childhood-onset asthma: An epigenetic link.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Microglia in autism spectrum disorder: heterogeneity, immunometabolism, and synapse-related pathways.Frontiers in immunology · 2026Review
- Microglia as critical mediators linking perinatal immune stress to mental health trajectories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prenatal Exposure to Fine Particulate Matter Components and Autism Risk in Childhood.JAMA network open · 2025Article
- Developmental functions of microglia: Impact of psychosocial and physiological early life stress.Neuropharmacology · 2024Review
- The role of microglia in early neurodevelopment and the effects of maternal immune activation.Seminars in immunopathology · 2024Review
- Development of a High-Throughput Pipeline to Characterize Microglia Morphological States at a Single-Cell Resolution.eNeuro · 2024Article
- Preclinical models of maternal asthma and progeny outcomes: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders.Biological psychiatry global open science · 2024Article
- Characterizing the neuroimmune environment of offspring in a novel model of maternal allergic asthma and particulate matter exposure.Journal of neuroinflammation · 2023Article
- Maternal Chronic Ultrasound Stress Provokes Immune Activation and Behavioral Deficits in the Offspring: A Mouse Model of Neurodevelopmental Pathology.International journal of molecular sciences · 2023Article
- Correlation of mutated gene and signalling pathways in ASD.IBRO neuroscience reports · 2023Review
- Modelling Microglial Innate Immune Memory In Vitro: Understanding the Role of Aerobic Glycolysis in Innate Immune Memory.International journal of molecular sciences · 2023Article
- Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder.Frontiers in neuroscience · 2023Review
- Maternal autoimmune disease and risk of offspring autism spectrum disorder - a nationwide population-based cohort study.Frontiers in psychiatry · 2023Article
- Sex Differences in Neurodevelopmental Disorders: A Key Role for the Immune System.Current topics in behavioral neurosciences · 2023Article
- Cell-type-specific epigenetic effects of early life stress on the brain.Translational psychiatry · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Dysregulation in immune responses during pregnancy increases the risk of a having a child with an autism spectrum disorder (ASD). Asthma is one of the most common chronic diseases among pregnant women, and symptoms often worsen during pregnancy. We recently developed a mouse model of maternal allergic asthma (MAA) that induces changes in sociability, repetitive, and perseverative behaviors in the offspring. Since epigenetic changes help a static genome adapt to the maternal environment, activation of the immune system may epigenetically alter fetal microglia, the brain's resident immune cells. We therefore tested the hypothesis that epigenomic alterations to microglia may be involved in behavioral abnormalities observed in MAA offspring. We used the genome-wide approaches of whole genome bisulfite sequencing to examine DNA methylation and RNA sequencing to examine gene expression in microglia from juvenile MAA offspring. Differentially methylated regions were enriched for immune signaling pathways and important microglial developmental transcription factor binding motifs. Differential expression analysis identified genes involved in controlling microglial sensitivity to the environment and shaping neuronal connections in the developing brain. Differentially expressed genes significantly overlapped genes with altered expression in human ASD cortex, supporting a role for microglia in the pathogenesis of ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.