Evidence map›Paper›PMID 29134686›Full record

ArticleMagnetic resonance in medicine2018

Selective proton-observed, carbon-edited (selPOCE) MRS method for measurement of glutamate and glutamine

Henk M De Feyter, Raimund I Herzog, Bart R Steensma, Dennis W J Klomp, Peter B Brown, Graeme F Mason, Douglas L Rothman, Robin A de Graaf

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Reproducibility of the Determination ofNMR in biomedicine · 2025
    Article
  3. Review
  4. Measurement of glucose metabolism in the occipital lobe and frontal cortex after oral administration of [1-13C]glucose at 9.4 T.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  5. Detection ofScientific reports · 2022
    Article
  6. Article
  7. Article
  8. HyperpolarizedJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Review
  9. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  10. Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Henk M De FeyterDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Raimund I HerzogDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Bart R SteensmaDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Dennis W J KlompDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Peter B BrownDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Graeme F MasonDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Douglas L RothmanDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Robin A de GraafDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Yale University · USResonance Research (United States) · USUniversity Medical Center Utrecht · NL

Funding

Regulation of Brain Glucose Metabolism in Type 1 DiabetesR01DK101984 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO · 2014 to 2023
$3.8M
Brain Acetate and Ethanol Metabolism in Alcohol Dependence and AbuseR01AA021984 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2013 to 2017
$2.7M
13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1M
Reversing brain metabolic adaptations to recurrent hypoglycemia in older adults with type 1 diabetes using a Predictive Low Glucose Management (PLGM) systemDP3DK112227 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO, WEINZIMER, STUART ALAN · 2016 to 2016
$1.9M
NIAAA NIH HHS R01 AA021984NIDDK NIH HHS DP3 DK112227NIDDK NIH HHS R01 DK101984NINDS NIH HHS R01 NS087568
6 · The paper itself

Abstract

purpose

methodsWe used an indirect (

resultsPhantom data illustrate how selPOCE can be tuned to selectively detect

conclusionsThe SelPOCE sequence allows the detection of

Indexed as

AdultBrain MappingCarbonFemaleFrontal LobeGlutamic AcidGlutamineHealthy VolunteersHumansImaging, Three-DimensionalKineticsMagnetic Resonance SpectroscopyMaleNeuroimagingNeurotransmitter AgentsPatient SafetyCarbonGlutamic AcidGlutamineNeurotransmitter AgentsProtons13Cfrontal lobehumanMRS

Identifiers

PMID29134686
PMCPMC5876108
OpenAlexW2769993180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.