Evidence map›Paper›PMID 29134614›Full record

Trial reportInternational urology and nephrology2018

Acute exercise during hemodialysis prevents the decrease in natural killer cells in patients with chronic kidney disease: a pilot study.

Maria Isabel Fuhro, Gilson P Dorneles, Francini P Andrade, Pedro R T Romão, Alessandra Peres, Mariane B Monteiro

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
    Pooled it
  5. Trial
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Isabel FuhroResearch Center, Methodist University Center IPA, Porto Alegre, Brazil.
Gilson P DornelesGraduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil. gilsonpd@hotmail.com.ORCID http://orcid.org/0000-0001-6524-3204
Francini P AndradeFederal University of Rio Grande do Sul, Porto Alegre, Brazil.
Pedro R T RomãoGraduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil.
Alessandra PeresResearch Center, Methodist University Center IPA, Porto Alegre, Brazil.
Mariane B MonteiroPhysical Therapy Department, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil. marianemonteiro@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted to intradialytic exercise in a randomized crossover study.

methodsNine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56

resultsHD therapy induced a significant decrease in NK cells frequency (p = 0.039), NK CD3-CD56

conclusionsThis study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.

Indexed as

Killer Cells, NaturalAgedCD3 ComplexCD56 AntigenC-Reactive ProteinCreatine KinaseCreatinineCross-Over StudiesExerciseFemaleHumansHydrocortisoneLymphocyte CountMaleMiddle AgedPhysical ExertionCD3 ComplexCD56 AntigenC-Reactive ProteinCreatine KinaseCreatinineHydrocortisoneUreaExerciseHemodialysisImmune responseInflammationNK cells

Identifiers

PMID29134614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.