ArticleBrain imaging and behavior2018
Altered connectivity patterns among resting state networks in patients with ischemic white matter lesions.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Changes in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT.Neuroradiology · 2021Trial
- Altered brain dynamics in post-stroke cognitive and motor dysfunction.Frontiers in aging neuroscience · 2025Article
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alterations in Dynamic Functional Connectivity in Patients with Cerebral Small Vessel Disease.Translational stroke research · 2024Article
- Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients.medRxiv : the preprint server for health sciences · 2024Article
- Aberrant intra- and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia.CNS neuroscience & therapeutics · 2023Article
- Atlasing white matter and grey matter joint contributions to resting-state networks in the human brain.Communications biology · 2023Article
- Reproducibility of regional structural and functional MRI networks in cerebral small vessel disease compared to age matched and stroke-free controls.Cerebral circulation - cognition and behavior · 2023Article
- Changes in white matter functional networks during wakefulness and sleep.Human brain mapping · 2022Article
- The functional and structural neural correlates of dynamic balance impairment and recovery in persons with acquired brain injury.Scientific reports · 2022Article
- Altered brain activity mediates the relationship between white matter hyperintensity severity and cognition in older adults.Brain imaging and behavior · 2022Article
- Lacunar infarction aggravates the cognitive deficit in the elderly with white matter lesion.Open life sciences · 2022Article
- Use of random matrix theory in the discovery of resting state brain networks.Magnetic resonance imaging · 2021Article
- Sweat the Fall Stuff: Physical Activity Moderates the Association of White Matter Hyperintensities With Falls Risk in Older Adults.Frontiers in human neuroscience · 2021Article
- Scalp Acupuncture Enhances the Functional Connectivity of Visual and Cognitive-Motor Function Network of Patients with Acute Ischemic Stroke.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Altered Granger Causal Connectivity of Resting-State Neural Networks in Patients With Leukoaraiosis-Associated Cognitive Impairment-A Cross-Sectional Study.Frontiers in neurology · 2020Article
- Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study.Neural plasticity · 2019Article
- Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis.Medical science monitor : international medical journal of experimental and clinical research · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
White matter lesions (WMLs) have been associated with cognitive and motor decline. Resting state networks (RSNs) are spatially coherent patterns in the human brain and their interactions sustain our daily function. Therefore, investigating the altered intra- and inter-network connectivity among the RSNs may help to understand the association of WMLs with impaired cognitive and motor function. Here, we assessed alterations in functional connectivity patterns based on six well-defined RSNs-the default mode network (DMN), dorsal attention network (DAN), frontal-parietal control network (FPCN), auditory network (AN), sensory motor network (SMN) and visual network (VN)-in 15 patients with ischemic WMLs and 15 controls. In the patients, Spearman's correlation analysis was further performed between these alterations and cognitive test scores, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Our results showed wide alterations of inter-network connectivity mainly involving the SMN, DMN, FPCN and DAN, and some alterations correlated with cognitive test scores in the patients. The reduced functional connectivities in the SMN-AN, SMN-VN, FPCN-AN, DAN-VN pairs may account for the cognitive and motor decline in patients with ischemic WMLs, while the increased functional connectivities in the DMN-AN, DMN-FPCN and DAN-FPCN pairs may reflect a functional network reorganization after damage to white matter. It is unexpected that altered intra-network connectivities were found within the AN and VN, which may explain the impairments in verbal fluency and information retrieval associated with WMLs. This study highlights the importance of functional connectivity in understanding how WMLs influence cognitive and behavior dysfunction.
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