Evidence map›Paper›PMID 29134609›Full record

ArticleJournal of endocrinological investigation2018

Expression of p27

E B Conemans, G M Raicu-Ionita, C R C Pieterman, K M A Dreijerink, O M Dekkers, A R Hermus, W W de Herder, M L Drent, A N A van der Horst-Schrivers, B Havekes and 6 more

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PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Menin in Cancer.Genes · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

E B ConemansDepartment of Surgery, University Medical Center Utrecht, PO box 85500, 3508 GA, Utrecht, The Netherlands.
G M Raicu-IonitaDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
C R C PietermanDepartment of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
K M A DreijerinkDepartment of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
O M DekkersDepartment of Endocrinology and Metabolism and Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
A R HermusDepartment of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.
W W de HerderDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
M L DrentDepartment of Internal Medicine, Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
A N A van der Horst-SchriversDepartment of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands.
B HavekesDepartment of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, Maastricht, The Netherlands.
P H BisschopDepartment of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
G J OfferhausDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
I H M Borel RinkesDepartment of Surgery, University Medical Center Utrecht, PO box 85500, 3508 GA, Utrecht, The Netherlands.
G D ValkDepartment of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
H Th M TimmersSection Stem Cells, Regenerative Medicine Center and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
M R VriensDepartment of Surgery, University Medical Center Utrecht, PO box 85500, 3508 GA, Utrecht, The Netherlands. mvriens@umcutrecht.nl.
University Medical Center Utrecht · NLAcademic Medical Center · NLAmsterdam UMC Location VUmc · NLErasmus MC · NLLeiden University Medical Center · NLMaastricht University · NLRadboud University Medical Center · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePancreatic neuroendocrine tumors are a major manifestation of multiple endocrine neoplasia type 1 (MEN1). This tumor syndrome is caused by germline mutations in MEN1, encoding menin. Insight into pathogenesis of these tumors might lead to new biomarkers and therapeutic targets for these patients. Several lines of evidence point towards a role for p27

methodsIn this study, we characterized protein expression of p27

resultsExpression of p27

conclusionsThese findings indicate that loss of p18

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p18Cyclin-Dependent Kinase Inhibitor p27FemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple Endocrine Neoplasia Type 1Neuroendocrine TumorsPancreatic NeoplasmsPrognosisYoung AdultBiomarkers, TumorCDKN1B protein, humanCDKN2C protein, humanCyclin-Dependent Kinase Inhibitor p18Cyclin-Dependent Kinase Inhibitor p27MeninMultiple endocrine neoplasia type 1p18Ink4cp27Kip1Pancreatic neuroendocrine tumors

Identifiers

PMID29134609
OpenAlexW2768161154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.