Trial reportPediatric nephrology (Berlin, Germany)2018
Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times.
Trial report in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01092260 (Glomerular Filtration Rate in Children - a Methodological Study With Iohexol Clearance), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glomerular Filtration Rate in Children - a Methodological Study With Iohexol Clearance
Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination.Scientific reports · 2021Trial
- Toward the Future: A Race-Agnostic, Bayesian Approach to Defining Glomerular Filtration for Personalized Drug Dosing.Clinical pharmacology and therapeutics · 2026Review
- Glomerular Filtration Rate Assessment in Children.Children (Basel, Switzerland) · 2022Review
- Iohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve.BMC nephrology · 2021Article
- Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation.Disease markers · 2020Article
- Comparative physiology of glomerular filtration rate by plasma clearance of exogenous creatinine and exo-iohexol in six different avian species.Scientific reports · 2019Article
- Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations.Pediatric nephrology (Berlin, Germany) · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe non-ionic agent iohexol is increasingly used as the marker of choice for glomerular filtration rate (GFR) measurement. Estimates of GFR in children have low accuracy and limiting the number of blood-draws in this patient population is especially relevant. We have performed a study to evaluate different formulas for calculating measured GFR based on plasma iohexol clearance with blood sampling at only one time point (GFR1p) and to determine the optimal sampling time point.
methodsNinety-six children with chronic kidney disease (CKD) stage 1-5 (median age 9.2 years; range 3 months to 17.5 years) were examined in a cross-sectional study using iohexol clearance and blood sampling at seven time points within 5 h (GFR7p) as the reference method. Median GFR7p was 66 (range 6-153) mL/min/1.73 m
resultsThe GFR1p calculated according to Fleming with sampling at 3 h (GFR1p
conclusionsFor determination of mGFR in children with CKD and an assumed GFR of ≥ 30 mL/min/1.73 m CLINICAL
trial registrationClinicalTrials.gov , Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.